Table 4.
Use of HEMOLEVEN during surgery (n = 14) in nine FXI-deficient patients with a basal factor XI level >20 IU dL−1
| Number of doses |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Intervention | UPN | Gender, Age, Level (IU dL−1) | Presurgery | Post surgery | First infusion dose (U kg−1) | T0.5 h Postinf. levels | Efficacy rating | Side effects | RBC units (day of transfusion) | Tranexamic acid (days of treatment) |
| Cardio surgery | ||||||||||
| Aortic valve replacement | 34-05 | M, 66 y., 22 | 1 | 1 | 23 | 62 | Excellent | No | No | No |
| Dental | ||||||||||
| Multiple wisdom tooth extraction* | 23-02 | M, 80 y., 29 | 1 | 0 | 10 | Excellent | No | No | No | |
| Obstetric, Gynaecological and abdominal surgery | ||||||||||
| Hysterectomy* | 36-08 | F, 40 y., 37 | 1 | 1 | 20 | 56† | Excellent | No | No | Yes (D1:D10) |
| Laparotomy with pelvic surgery* | 36-05 | F, 61 y., 38 | 1 | 1 | 14 | 81 | Good | No | No | No |
| Correction of annexal torsion on ovarian cyst by coelioscopy | F, 31 y., 38 | 1 | 0 | 13 | Excellent | No | No | No | ||
| Caesarean* | 36-09 | F, 29 y., 41 | 1 | 0 | 32 | 77 | NA | No | Yes (D1) | Yes (D1) |
| Liver biopsy | 34-05 | M, 65 y., 22 | 1 | 0 | 11 | 30 | Excellent | No | No | No |
| Hepatectomy | 34-05 | M, 66 y., 22 | 1 | 3 | 22 | 68 | Excellent | No | Yes (D1) | Yes (D1:D11) |
| ENT surgery | ||||||||||
| Ethmoidectomy | 22-03 | F, 25 y., 31 | 1 | 1 | 20 | Excellent | No | No | Yes (D1:D2) | |
| Ethmoidectomy | 22-03 | F, 26 y., 31 | 1 | 1 | 20 | Excellent | Site pain | No | No | |
| Tympanoplasty | 22-01 | M, 60 y., 35 | 1 | 3 | 12 | 43† | Excellent | No | No | No |
| Tympanoplasty/ossiculoplasty | 22-01 | M, 61 y., 35 | 1 | 1 | 10 | Excellent | No | No | No | |
| Urological | ||||||||||
| Endoscopic urethrotomy* | 23-02 | M, 80 y., 29 | 1 | 0 | 12 | Excellent | No | |||
| Vascular | ||||||||||
| Stripping of varices | 35-01 | F, 49 y., 35 | 1 | 0 | 17 | Excellent | No | v | ||
M, Male; F, Female; y., years; D1, Day of surgery; RBC, Red Blood Cells.
*
Surgery at a site with fibrinolytic activity.
†
Blood sample drawn within 2 h post infusion.