Table 1.
Total and live birth prevalence of neutral tube defects in study population, European Surveillance of Congenital Anomalies (EUROCAT), 1991-2011
| Place | Time period | Total births | Total live births | Neural tube defects* | Anencephaly | Spina bifida | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No | Prevalence per 10 000 births | No | Prevalence per 10 000 births | No | Prevalence per 10 000 births | ||||||
| Austria, Styria | 1991-2009 | 216 196 | 215 388 | 166 | 7.68 | 40 | 1.85 | 98 | 4.53 | ||
| Belgium, Antwerp | 1991-2011 | 337 862 | 336 481 | 283 | 8.38 | 100 | 2.96 | 156 | 4.62 | ||
| Belgium, Hainaut | 1991-2011 | 263 703 | 262 493 | 247 | 9.37 | 82 | 3.11 | 135 | 5.12 | ||
| Czech Republic | 2000-09 | 1 029 247 | 1 026 352 | 769 | 7.47 | 245 | 2.38 | 410 | 3.98 | ||
| Croatia, Zagreb | 1991-2010 | 131 525 | 130 913 | 63 | 4.79 | 18 | 1.37 | 36 | 2.74 | ||
| Denmark, Odense | 1991-2011 | 115 846 | 115 231 | 127 | 10.96 | 44 | 3.80 | 68 | 5.87 | ||
| Finland | 1993-2010 | 1 070 940 | 1 066 986 | 928 | 8.67 | 314 | 2.93 | 436 | 4.07 | ||
| France, Paris | 1991-2011 | 666 353 | 660 950 | 801 | 12.02 | 347 | 5.21 | 331 | 4.97 | ||
| Germany, Mainz† | 1991-2011 | 71 627 | 71 343 | 134 | 18.72 | 28 | 3.91 | 85 | 11.87 | ||
| Germany, Saxony-Anhalt | 1991-2011 | 289 124 | 287 850 | 258 | 8.93 | 67 | 2.32 | 151 | 5.22 | ||
| Hungary | 1998-2010 | 1 260 719 | 1 254 111 | 847 | 6.72 | 256 | 2.03 | 498 | 3.95 | ||
| Ireland, Cork and Kerry | 1996-2010 | 131 168 | 130 443 | 159 | 12.13 | 65 | 4.96 | 83 | 6.33 | ||
| Ireland, Dublin | 1991-2011 | 470 231 | 467 901 | 411 | 8.74 | 149 | 3.17 | 201 | 4.28 | ||
| Ireland, south east | 1997-2011 | 101 348 | 101 269 | 97 | 9.58 | 30 | 2.96 | 63 | 6.22 | ||
| Italy, Emilia Romagna | 1991-2011 | 656 637 | 654 627 | 350 | 5.33 | 109 | 1.66 | 202 | 3.08 | ||
| Italy, Tuscany | 1991-2011 | 558 669 | 556 582 | 313 | 5.60 | 108 | 1.93 | 163 | 2.92 | ||
| Malta | 1991-2010 | 88 573 | 88 202 | 97 | 10.95 | 25 | 2.82 | 56 | 6.32 | ||
| Netherlands, northern | 1991-2011 | 401 404 | 399 055 | 338 | 8.42 | 108 | 2.69 | 197 | 4.91 | ||
| Norway | 1999-2011 | 775 060 | 769 293 | 718 | 9.27 | 282 | 3.64 | 360 | 4.65 | ||
| Poland, Wielkopolska | 1999-2010 | 440 163 | 437 966 | 407 | 9.25 | 71 | 1.61 | 290 | 6.59 | ||
| Portugal, southern | 1991-2010 | 316 853 | 315 491 | 150 | 4.73 | 62 | 1.96 | 76 | 2.40 | ||
| Spain, Basque Country | 1991-2010 | 361 416 | 359 810 | 356 | 9.85 | 189 | 5.23 | 141 | 3.90 | ||
| Switzerland, Vaud | 1991-2011 | 159 273 | 158 617 | 162 | 10.17 | 62 | 3.89 | 74 | 4.65 | ||
| United Kingdom, East Midlands and South Yorkshire | 1998-2011 | 922 288 | 916 786 | 1012 | 10.97 | 426 | 4.62 | 480 | 5.21 | ||
| UK, northern England | 2000-2011 | 382 973 | 380 843 | 522 | 13.63 | 214 | 5.59 | 251 | 6.56 | ||
| UK, Thames Valley | 1991-2011 | 291 827 | 290 307 | 337 | 11.55 | 155 | 5.31 | 156 | 5.35 | ||
| UK, Wales | 1998-2011 | 466 358 | 463 941 | 703 | 15.08 | 278 | 5.96 | 330 | 7.08 | ||
| UK, Wessex | 1994-2011 | 492 629 | 490 436 | 598 | 12.14 | 288 | 5.85 | 249 | 5.06 | ||
| Total (95% CI) | 1991-2011 | 12 470 012 | 12 409 667 | 11 353 | 9.105 (8.94 to 9.27) | 4162 | 3.34 (3.24 to 3.44) | 5776 | 4.63 (4.51 to 4.75) | ||
*Total number comprises cases of anencephaly, spina bifida, and encephalocele.
†Higher prevalence of neural tube defects (NTD), specifically spina bifida, has been consistent observation in Mainz; substantial fluctuations in prevalence of NTD in Mainz occurred over time, however (as in other registries), and no evidence was found that lack of clear downward trend in prevalence of NTD in overall data could be explained by any changes in Mainz.