Table 2.
Top platelet membrane integral proteins identified by LC-MS
| Name | Functions | Receptors |
|---|---|---|
| THBS1 | Platelet adhesion | Fibrinogen, fibronectin, laminin, and collagen |
| Integrin α 2b (CD41) | αIIbβ3 complex, platelet adhesion and aggregation | Fibrinogen, fibronectin, vWF |
| Integrin β, β3 (CD61) | αIIbβ3 complex, platelet adhesion and aggregation | Fibrinogen, fibronectin, vWF |
| GP Ib α (CD42b) | GPIb-V-IX complex, platelet adhesion | vWF |
| GP Ib β (CD42c) | GPIb-V-IX complex, platelet adhesion | vWF |
| GP IX | GPIb-V-IX complex, platelet adhesion | vWF |
| GP V | GPIb-V-IX complex, platelet adhesion | vWF |
| GP VI | Initial platelet adhesion | Collagen |
| MHC-1 | Host recognition, self compatibility | CD8 receptor |
| CD47 | Anti-phagocytosis | Signal regulatory protein-α (SIRPα) |
| P-selectin | Platelet adhesion | PSGL-1 (decorated with sLex) |