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. Author manuscript; available in PMC: 2016 Oct 12.
Published in final edited form as: Chembiochem. 2015 Sep 9;16(15):2205–2215. doi: 10.1002/cbic.201500348

Scheme 1.

Scheme 1

AChE activity, inhibition, and reactivation. A) AChE functions to hydrolyze the neurotransmitter acetylcholine. B) The catalytic triad of the active site of AChE is vulnerable to inhibition by organophosphates. C) Examples of common organophosphates used as active principles in pesticides and nerve agents that covalently modify the serine residue in the AChE active site.