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. Author manuscript; available in PMC: 2016 Oct 12.
Published in final edited form as: Chembiochem. 2015 Sep 9;16(15):2205–2215. doi: 10.1002/cbic.201500348

Figure 1.

Figure 1

Newly identified reactivators of AChE. A) Structures of the traditional oxime reactivator pralidoxime (5) and of the recently identified hits from our screening assay: ADQ (6), and scopoletin (7). B), C) Concentration dependence of reactivation of paraoxon-inhibited (1-inhibited) human AChE: B) by scopoletin (7), or C) by ADQ (6). D) Concentration dependence of reactivation of 1-inhibited human (purple), mouse (blue), or guinea pig (orange) forms of AChE at increasing ADQ (6) concentrations. Reactivation was allowed for 3 h at room temperature. All reactions were repeated in triplicate or in duplicate on multiple days. Errors bars show the standard deviations.