Figure 8.

Clusters of sites prone to destabilizing mutations overlap with peptides shown to induce robust immune response and be associated with viral control. Positions prone to destabilizing mutations are underlined and bolded in HIV-1 Gag-p24 subtype B consensus sequence. Yellow regions depict four continuous stretches of sites found in three or more overlapping 15 amino acid windows with each window containing five or more destabilizing sites. CE peptides [3,14,41] and “Beneficial” peptides from [42] were previously shown to induce robust immune responses [43,44] and associated with viral control [42], respectively. * denote residues not included in all the template structures examined and, hence, excluded from the analysis.