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. 2015 Dec;100(12):1553–1563. doi: 10.3324/haematol.2015.130351

Figure 5.

Figure 5.

Combined treatment with INK128 and ABT-737 inactivates AKT and down-regulates Mcl-1 in AML cells. Western blot analysis in U937 (A–B) MV4-11 (C), and primary AML blasts isolated from 2 patients (D) following exposure to INK128 ± ABT-737 for the indicated intervals (for U937) or for 8 hrs (MV4-11 and primary blasts). The concentrations used in this study were: INK128: 200 nM for U937, 100 nM for MV4-11 and patient 4, 50 nM for patient 1. ABT-737: 500 nM for U937, 10 nM for MV4-11 and patient 4, and 25 nM for patient 1.