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. 1993 Jun 1;90(11):5242–5246. doi: 10.1073/pnas.90.11.5242

Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

O Pourquié 1, M Coltey 1, M A Teillet 1, C Ordahl 1, N M Le Douarin 1
PMCID: PMC46692  PMID: 8506372

Abstract

We have examined the effect of implantation of a supernumerary notochord or floor plate on dorsoventral somitic organization. We show that notochord and floor plate are able to inhibit the differentiation of the dorsal somitic derivatives--i.e., axial muscles and dermis--thus converting the entire somite into cartilage, which normally arises only from its ventral part. We infer from these results that the dorsoventral patterning of somitic derivatives is controlled by signals provided by ventral axial structures.

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Selected References

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  1. Aoyama H., Asamoto K. Determination of somite cells: independence of cell differentiation and morphogenesis. Development. 1988 Sep;104(1):15–28. doi: 10.1242/dev.104.1.15. [DOI] [PubMed] [Google Scholar]
  2. Christ B., Brand-Saberi B., Grim M., Wilting J. Local signalling in dermomyotomal cell type specification. Anat Embryol (Berl) 1992 Oct;186(5):505–510. doi: 10.1007/BF00185464. [DOI] [PubMed] [Google Scholar]
  3. Christ B., Wilting J. From somites to vertebral column. Ann Anat. 1992 Feb;174(1):23–32. doi: 10.1016/s0940-9602(11)80337-7. [DOI] [PubMed] [Google Scholar]
  4. Jeffs P., Osmond M. A segmented pattern of cell death during development of the chick embryo. Anat Embryol (Berl) 1992;185(6):589–598. doi: 10.1007/BF00185618. [DOI] [PubMed] [Google Scholar]
  5. KITCHIN I. C. The effects of notochordectomy in Amblystoma mexicanum. J Exp Zool. 1949 Dec;112(3):393–415. doi: 10.1002/jez.1401120303. [DOI] [PubMed] [Google Scholar]
  6. Ordahl C. P., Le Douarin N. M. Two myogenic lineages within the developing somite. Development. 1992 Feb;114(2):339–353. doi: 10.1242/dev.114.2.339. [DOI] [PubMed] [Google Scholar]
  7. Placzek M., Yamada T., Tessier-Lavigne M., Jessell T., Dodd J. Control of dorsoventral pattern in vertebrate neural development: induction and polarizing properties of the floor plate. Dev Suppl. 1991;Suppl 2:105–122. [PubMed] [Google Scholar]
  8. Pourquié O., Coltey M., Thomas J. L., Le Douarin N. M. A widely distributed antigen developmentally regulated in the nervous system. Development. 1990 Aug;109(4):743–752. doi: 10.1242/dev.109.4.743. [DOI] [PubMed] [Google Scholar]
  9. Pourquié O., Corbel C., Le Caer J. P., Rossier J., Le Douarin N. M. BEN, a surface glycoprotein of the immunoglobulin superfamily, is expressed in a variety of developing systems. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5261–5265. doi: 10.1073/pnas.89.12.5261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pownall M. E., Emerson C. P., Jr Sequential activation of three myogenic regulatory genes during somite morphogenesis in quail embryos. Dev Biol. 1992 May;151(1):67–79. doi: 10.1016/0012-1606(92)90214-2. [DOI] [PubMed] [Google Scholar]
  11. Rohkamm R. Degeneration and regeneration in neurons of the cerebellum. Adv Anat Embryol Cell Biol. 1977;53(6):1–118. doi: 10.1007/978-3-642-66818-0. [DOI] [PubMed] [Google Scholar]
  12. Rong P. M., Teillet M. A., Ziller C., Le Douarin N. M. The neural tube/notochord complex is necessary for vertebral but not limb and body wall striated muscle differentiation. Development. 1992 Jul;115(3):657–672. doi: 10.1242/dev.115.3.657. [DOI] [PubMed] [Google Scholar]
  13. Rong P. M., Ziller C., Pena-Melian A., Le Douarin N. M. A monoclonal antibody specific for avian early myogenic cells and differentiated muscle. Dev Biol. 1987 Aug;122(2):338–353. doi: 10.1016/0012-1606(87)90299-5. [DOI] [PubMed] [Google Scholar]
  14. STRUDEL G. L'action morphogène du tube nerveux et de la corde sur la différenciation des vertèbres et des muscles vertébraux chez l'embryon de poulet. Arch Anat Microsc Morphol Exp. 1955;44(3):209–235. [PubMed] [Google Scholar]
  15. Selleck M. A., Stern C. D. Fate mapping and cell lineage analysis of Hensen's node in the chick embryo. Development. 1991 Jun;112(2):615–626. doi: 10.1242/dev.112.2.615. [DOI] [PubMed] [Google Scholar]
  16. Smith J. L., Schoenwolf G. C. Notochordal induction of cell wedging in the chick neural plate and its role in neural tube formation. J Exp Zool. 1989 Apr;250(1):49–62. doi: 10.1002/jez.1402500107. [DOI] [PubMed] [Google Scholar]
  17. Stern C. D., Fraser S. E., Keynes R. J., Primmett D. R. A cell lineage analysis of segmentation in the chick embryo. Development. 1988;104 (Suppl):231–244. doi: 10.1242/dev.104.Supplement.231. [DOI] [PubMed] [Google Scholar]
  18. Teillet M. A., Le Douarin N. M. Consequences of neural tube and notochord excision on the development of the peripheral nervous system in the chick embryo. Dev Biol. 1983 Jul;98(1):192–211. doi: 10.1016/0012-1606(83)90349-4. [DOI] [PubMed] [Google Scholar]
  19. WATTERSON R. L., GOODHEART C. R., LINDBERG G. The influence of adjacent structures upon the shape of the neural tube and neural plate of chick embryos. Anat Rec. 1955 Aug;122(4):539–559. doi: 10.1002/ar.1091220405. [DOI] [PubMed] [Google Scholar]
  20. Yamada T., Placzek M., Tanaka H., Dodd J., Jessell T. M. Control of cell pattern in the developing nervous system: polarizing activity of the floor plate and notochord. Cell. 1991 Feb 8;64(3):635–647. doi: 10.1016/0092-8674(91)90247-v. [DOI] [PubMed] [Google Scholar]
  21. van Straaten H. W., Hekking J. W. Development of floor plate, neurons and axonal outgrowth pattern in the early spinal cord of the notochord-deficient chick embryo. Anat Embryol (Berl) 1991;184(1):55–63. doi: 10.1007/BF01744261. [DOI] [PubMed] [Google Scholar]
  22. van Straaten H. W., Hekking J. W., Thors F., Wiertz-Hoessels E. L., Drukker J. Induction of an additional floor plate in the neural tube. Acta Morphol Neerl Scand. 1985 Oct;23(2):91–97. [PubMed] [Google Scholar]

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