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. 2015 Dec 4;6:37. doi: 10.1186/s13227-015-0032-4

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© Bastin et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Conserved structural features of Platynereis Frizzled transmembrane receptors. Multiple alignments of full-length protein sequences for frizzled transmembrane receptors from Platynereis dumerilii (Pd) and Xenopus laevis (Xl) using MAFFT are shown. Gray box N-terminal hydrophobic localization signal. Purple box CRD domain showing conserved Cysteine residues in orange, and NXS/T motif in green. Green box Frizzled transmembrane domain. Purple boxes with asterisks: conserved ‘signature’ residues unique to each frizzled receptor class identified by Schenkelaars et al. (2012) [18], (Fz1/2/7: 1C–G–2C, Fz4: 1C–R–0C, Fz5/8: 3C–R–2C, Fz9/10: 1C–R–2C). Yellow box KTXXXW, PDZ binding motif. Blue box C-terminal ES/TXV motif of Fz1/2/7 and Fz4 homologs