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. 2015 Jun 10;6(26):22890–22904. doi: 10.18632/oncotarget.4413

Figure 2. BMPR1a deletion in mammary carcinomas results in EMT-like changes.

Figure 2

A. Representative image of IHC for the EMT associated transcription factor SNAIL. B. Representative image of IHC for the EMT associated transcription factor SLUG. C. Representative image of IHC for β-catenin in CTL tumors and cKO tumors. D. Representative image of IHC for E-cadherin in CTL tumors and in cKO tumors. E. Representative image of IF staining for both E-cadherin and Vimentin in CTL tumors and co-staining in cKO tumors. F. Representative image of Luminal (K8) and basal (K5) cytokeratins in CTL tumors and cKO tumors. G. Representative image of K5 and Vimentin in control and cKO tumors (dual staining indicated by white arrows). H. qPCR from whole primary tumors for Snail, Slug, and Zo-1. mRNA is normalized to Gapdh levels and relative to control tumors. Error bars indicate SEM. *p = < 0.05, **p = < 0.01. Scale bars indicate 200μm.