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. 2015 May 27;6(25):21468–21478. doi: 10.18632/oncotarget.4097

Figure 5. Nuclear HMW FGF2 activates Akt signaling pathway.

Figure 5

A. T98G cells were transfected with empty plasmid, HMW FGF2 or 18K-FGF2 respectively. Whole cell lysates were collected and subjected to western blot analysis using antibodies against HA, Kapβ2, PTEN, Akt and phosphorylated Akt (p-Akt). B. T98G cells expressing HMW FGF2 were transfected with scramble siRNA or siRNA against Kapβ2. Whole cell lysates were collected and subjected to western blot analysis using antibodies against HA, Kapβ2, PTEN, Akt and phosphorylated Akt (p-Akt). GAPDH was used as loading control. GAPDH was used as loading control.