Skip to main content
editorial
. 2015 Nov 23;2(11):913–914. doi: 10.18632/oncoscience.272

Figure 1. Multifaceted regulation of HIF-1α/VEGF-A via mTORC1 and STAT3.

Figure 1

Through RTKs, growth factors (IGF-1, Insulin, and PDGF) and cytokines (Interleukins) activate mTORC1 and STAT3, which are both upstream of HIF-1α. Downstream from both mTORC1 and JAK2, STAT3 drives HIF-1α mRNA gene-expression. mTORC1 through repression of the translation inhibitor, 4E-BP1, leads to enhanced translation of HIF-1α via eIF4E. S6K1 further enhances the translation rates of HIF-1α. Both STAT3 and HIF-1α drives angiogenesis through gene-expression of VEGF-A, while mTORC1 enhances VEGF-A translation via eIF4E.