Table 1.

Example calculation of raw KAR score for Kinase X

Drug	Sensitivity bin	Kinase X inhibited?	Δ score
1	1	Yes	20
2	2	No	0
3	5	Yes	−10
4	1	Yes	20
5	3	No	0
6	4	No	0

Note: If a drug inhibits Kinase X, points are added based on the sensitivity bin of the drug. For example, Drug 1 inhibits kinase X and is in sensitivity bin 1 (highest sensitivity), therefore 20 points are added to the score. Drugs that do not inhibit Kinase X do not affect the score (Drugs 2, 5 and 6). The total Raw score for Kinase X is calculated by summing over all the drugs in the panel.

Raw KAR Score = 20-10 + 20 = 30.