Abstract
The “Bio-Optics: Design and Application” symposium, held on April 12–15, 2015, in Vancouver, BC, was an important step in a continuous journey to closely connect technological design advancement and biomedical applications. The symposium presented a broad range of innovations in diagnostic devices, endoscopy, optical microscopy, optical coherence tomography, multi-modal imaging, and highlighted specific applications including cancer diagnostics, detection of infectious disease and point of care, as well as microsurgery treatment.
OCIS codes: (000.1200) Announcements, awards, news, and organizational activities; (000.0000) General
Optical instrumentation for bio-imaging is an important component of biological and medical science progress. On the other hand, biomedical applications are critical drivers for technology development in optics and photonics. The development of optics in biological and biomedical sciences (i.e.,bio-optics) requires not only deep insight into the applications but also the synergistic collaborations of many fields, including optics, electronics, metrology, micro/nano fabrication, sensors, contrast agents and probes and many others. The range of applications is very broad as well, from medical diagnostics and treatment to basic research to understand how living organisms behave and work. The connection between application and technology development is a great challenge but also a great opportunity. In particular, new method development and instrument design can lead to new discoveries, open new avenues to solve untouched/outstanding problems, and enable new applications and new ideas. This is why both “Design and Application” need to be always in a close alliance. The “Bio-Optics: Design and Application” symposium, held on April 12–15, 2015, in Vancouver, BC, was an important step in a continuous journey to closely connect technological design advancement and biomedical applications. The symposium presented a broad range of innovations in diagnostic devices, endoscopy, optical microscopy, optical coherence tomography, multi-modal imaging, and highlighted specific applications including cancer diagnostics, detection of infectious disease and point of care, as well as microsurgery treatment. In this feature issue of Biomedical Optics Express, we have collected several papers that represent some of the technologies discussed at the Bio-Optics: Design and Application. These papers highlight advances in diagnostic microscopy [1–5], optical coherence tomography [6], multimodal imaging [7,8] and selected applications [9,10]. Together, they present a set of interesting instrumentation developments in the field biomedical optics.
References and links
- 1.Lin X., Wu J., Zheng G., Dai Q., “Camera array based light field microscopy,” Biomed. Opt. Express 6(9), 3179–3189 (2015). 10.1364/BOE.6.003179 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Guo K., Liao J., Bian Z., Heng X., Zheng G., “InstantScope: a low-cost whole slide imaging system with instant focal plane detection,” Biomed. Opt. Express 6(9), 3210–3216 (2015). 10.1364/BOE.6.003210 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Burnett J. L., Carns J. L., Richards-Kortum R., “In vivo microscopy of hemozoin: towards a needle free diagnostic for malaria,” Biomed. Opt. Express 6(9), 3462–3474 (2015). 10.1364/BOE.6.003462 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Vigil G. D., Howard S. S., “Photophysical characterization of sickle cell disease hemoglobin by multi-photon microscopy,” Biomed. Opt. Express 6(10), 4098–4104 (2015). 10.1364/BOE.6.004098 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 5.Forcucci A., Pawlowski M. E., Majors C., Richards-Kortum R., Tkaczyk T. S., “All-plastic, miniature, digital fluorescence microscope for three part white blood cell differential measurements at the point of care,” Biomed. Opt. Express 6(11), 4433–4446 (2015). 10.1364/BOE.6.004433 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 6.Zhao Y., Maher J. R., Kim J., Selim M. A., Levinson H., Wax A., “Evaluation of burn severity in vivo in a mouse model using spectroscopic optical coherence tomography,” Biomed. Opt. Express 6(9), 3339–3345 (2015). 10.1364/BOE.6.003339 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 7.Leung H. M., Gmitro A. F., “Fluorescence and reflectance spectral imaging system for a murine mammary window chamber model,” Biomed. Opt. Express 6(8), 2887–2894 (2015). 10.1364/BOE.6.002887 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 8.Tanha K., Pashazadeh A. M., Pogue B. W., “Review of biomedical Čerenkov luminescence imaging applications,” Biomed. Opt. Express 6(8), 3053–3065 (2015). 10.1364/BOE.6.003053 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 9.Feng S., Wang W., Tai I. T., Chen G., Chen R., Zeng H., “Label-free surface-enhanced Raman spectroscopy for detection of colorectal cancer and precursor lesions using blood plasma,” Biomed. Opt. Express 6(9), 3494–3502 (2015). 10.1364/BOE.6.003494 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 10.Jung D. S., Crowe J. A., Birchall J. P., Somekh M. G., See C. W., “Anti-confocal versus confocal assessment of the middle ear simulated by Monte Carlo methods,” Biomed. Opt. Express 6(10), 3820–3825 (2015). 10.1364/BOE.6.003820 [DOI] [PMC free article] [PubMed] [Google Scholar]