Table 3.
Associations Between Risk Factors and Cogstate Composite Scores*
| DET + IDN (n=1,580) (psychomotor speed, attention) |
OCL + ONB (n=1,505) (learning, working memory) |
Overall Cognition (n=1,469) |
||||
|---|---|---|---|---|---|---|
| β | p | β | P | Β | P | |
| Age (years) | −0.03 (−0.04, −0.02) | <0.001 | −0.04 (−0.04, −0.03) |
<0.001 | −0.03 (−0.04, −0.03) |
<0.001 |
| Body mass index | ||||||
| <22 kg/m2 | −0.01 (−0.18, 0.17) | 0.95 | −0.08 (−0.22, 0.07) | 0.29 | −0.03 (−0.16, 0.10) |
0.64 |
| 22–24.9 kg/m2 (ref.) | - | - | - | - | - | - |
| 25–29.9 kg/m2 | 0.03 (−0.08, 0.13) | 0.62 | 0.00 (−0.09, 0.09) | 0.97 | 0.02 (−0.07, 0.10) | 0.71 |
| 30+ kg/m2 | 0.11 (−0.04, 0.26) | 0.15 | 0.04 (−0.09, 0.16) | 0.57 | 0.06 (−0.05, 0.18) | 0.28 |
| Physical activity, MET- hr/wk |
||||||
| First quartile (ref.) | - | - | - | - | - | - |
| Second quartile | 0.04 (−0.08, 0.17) | 0.51 | 0.04 (−0.07, 0.15) | 0.51 | 0.01 (−0.09, 0.11) | 0.79 |
| Third quartile | 0.00 (−0.13, 0.13) | 0.97 | 0.00 (−0.12, 0.11) | 0.94 | −0.03 (−0.13, 0.08) |
0.61 |
| Fourth quartile | 0.07 (−0.06, 0.20) | 0.29 | 0.01 (−0.11, 0.12) | 0.92 | 0.00 (−0.10, 0.10) | 0.99 |
| p-trend | 0.38 | 0.82 | 0.85 | |||
| Alcohol, servings/day | ||||||
| None (ref.) | - | - | - | - | - | - |
| 1–2 | 0.08 (−0.02, 0.18) | 0.10 | 0.03 (−0.05, 0.11) | 0.51 | 0.04 (−0.03, 0.12) | 0.27 |
| >2 | −0.04 (−0.17, 0.10) | 0.58 | −0.02 (−0.13, 0.10) | 0.76 | −0.03 (−0.14, 0.07) |
0.53 |
| Nut Intake, servings | ||||||
| <1/month (ref.) | - | - | - | - | - | - |
| 1–3/month | −0.03 (−0.22, 0.16) | 0.76 | 0.10 (−0.07, 0.26) | 0.25 | 0.04 (−0.11, 0.18) | 0.64 |
| 1–2/week | 0.09 (−0.07, 0.24) | 0.29 | 0.16 (0.02, 0.29) | 0.02 | 0.12 (0.00, 0.25) | 0.05 |
| >2/week | 0.10 (−0.05, 0.26) | 0.20 | 0.17 (0.04, 0.30) | 0.01 | 0.15 (0.03, 0.27) | 0.01 |
| p-trend | 0.16 | 0.08 | 0.02 | |||
| Fish Intake, servings | ||||||
| <1/month (ref.) | - | - | - | - | - | - |
| 1–3/month | −0.01 (−0.22, 0.20) | 0.91 | −0.13 (−0.30, 0.05) | 0.15 | −0.08 (−0.24, 0.08) |
0.33 |
| 1–2/week | 0.08 (−0.09, 0.26) | 0.36 | −0.03 (−0.18, 0.11) | 0.65 | 0.02 (−0.11, 0.16) | 0.72 |
| >2/week | 0.05 (−0.14, 0.23) | 0.61 | −0.04 (−0.20, 0.12) | 0.61 | 0.01 (−0.13, 0.15) | 0.93 |
| p-trend | 0.72 | 0.75 | 0.60 | |||
| Diabetes | −0.16 (−0.32, 0.00) | 0.04 | 0.10 (−0.03, 0.24) | 0.14 | −0.05 (−0.17, 0.08) |
0.47 |
| Hypertension | −0.07 (−0.16, 0.02) | 0.11 | −0.08 (−0.16, 0.00) | 0.04 | −0.08 (−0.15, −0.01) |
0.03 |
| Myocardial infarction | 0.09 (−0.08, 0.26) | 0.31 | 0.02 (−0.13, 0.16) | 0.82 | 0.04 (−0.09, 0.18) | 0.51 |
*
Higher scores indicate better performance. All variables were placed into the same model