Table 1. Demographics and clinicopathologic characteristics of the NET cohort who underwent liver directed surgery.
The single PNET patient with a familial syndrome had MEN1.
| PNET (n=28) | SBNET (n=80) | p value | |
|---|---|---|---|
| Sex | |||
| M | 13 (46.4%) | 49 (61.3%) | .25 |
| F | 15 (53.6%) | 31 (38.8%) | .25 |
| Median age at surgery | 54.7 (22.68-79.26) | 60.3 (15-80.5) | .01 |
| Grade | |||
| G1/G2 | 25 (89.3%) | 74 (92.5%) | .89 |
| G3 | 2 (7.1%) | 2 (2.5%) | .59 |
| Not graded | 1 (3.6%) | 4 (5.0%) | 1 |
| Multifocal primary | 1 (3.6%) | 39 (48.8%) | < .001 |
| Functional primary tumor | 3 (10.7%) | 56 (70.0%) | < .001 |
| T stage | |||
| T1 | 8 (28.6%) | 2 (2.5%) | < .001 |
| T2 | 16 (57.1%) | 12 (15.0%) | < .001 |
| T3 | 2 (7.1%) | 29 (36.3%) | < .001 |
| T4 | 2 (7.1%) | 34 (42.5%) | < .001 |
| N stage | |||
| N0 | 4 (14.3%) | 9 (11.3%) | .93 |
| N1 | 21 (75.0%) | 70 (87.5%) | .21 |
| Distant metastases (non-liver, non-LN) | 3 (10.7%) | 40 (50.0%) | < .001 |
| Familial syndrome | 1 (3.6%) | NA | |
| Preoperative symptoms | |||
| Abdominal pain only | 8 (30%) | 15 (19%) | .37 |
| Abdominal pain + diarrhea and/or flushing | 7 (26%) | 36 (46%) | .12 |
| Diarrhea and/or flushing only | 5 (19%) | 20 (25%) | .65 |
| No symptoms | 7 (26%) | 8 (10%) | .50 |
| Non-surgical therapies | |||
| Octreotide | 25 (89.3%) | 66 (82.5%) | .58 |
| Hepatic arterial embolization | 6 (21.4%) | 14 (17.5%) | .86 |
| Systemic chemotherapy | 14 (50.0%) | 6 (7.5%) | < .001 |
| Peptide receptor radionuclide therapy | 2 (7.1%) | 13 (16.3%) | .38 |