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Schematic representation of the mechanism of the antithrombosis effect by miR-148a inhibition. Depicted is the ITAM-Syk pathway and the proposed role of TULA-2, miR-148a, and anti–miR-148a. Anti–miR-148a indirectly ameliorates ITAM-Syk–mediated platelet activation by upregulating TULA-2 expression, which further inactivates Syk and its downstream effectors.
