Cohort average signal enhancement curves. Post-contrast signal enhancement versus time obtained from the median signal intensity in each tissue type (NAWM: normal-appearing white matter, WMH: white matter hyperintensities, DGM: deep grey matter, RSL: recent stroke lesion, SS: sagittal sinus) and averaged over all patients (n = 201). Y-axis scales for the tissue and sagittal sinus enhancement curves are shown on the left and right, respectively.