Figure 2.

[Introduction] Diagnostic algorithm for patients with suspected non-small cell lung cancer.The initial evaluation provides information on comorbidities, functional status, preferences, and probable extent of disease. The results of the initial evaluation determine the optimal site and sequencing of additional diagnostic and staging tests. Staging and diagnosis will be most efficient if the most advanced site of disease is targeted first. *When there is overwhelming imaging evidence of distant metastases, biopsy of the most accessible site is sufficient. DLCO = diffusing capacity of lung for carbon monoxide; EBUS-NA = endobronchial ultrasound-guided needle aspiration.