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. 2015 Jul 28;6(28):24842–24855. doi: 10.18632/oncotarget.4704

Figure 3. Bell Model kinetic properties of protein-protein and cell-protein interactions.

Figure 3

A, C. Unstressed off-rate (s−1) and B, D. reactive compliance (nm) for MUC16 and PODXL interactions with E/L-selectin using a range of retraction velocities (5–25 μm/s). Data represent mean ± S.D. of 3–5 independent experiments which each had at least 1, 250 approach/retract cycles. Cantilever tips coated with E/L-selectin were brought in contact with immunopurified MUC16 or PODXL incorporated lipid bilayers or MUC16-expressing (PODXL-KD) or PODXL-expressing (MUC16-KD) SW1990 cells. *P < 0.05 with respect to both MUC16-L-selectin and PODXL-KD SW1990-L-selectin in (A). *P < 0.05 with respect to both PODXL-L-selectin and MUC16-KD SW1990-L-selectin interactions in (C). *P < 0.05 with respect to the indicated interactions (B, D).