Figure 4. Heparin derivatives prevent galectin-3 mediated metastasis of human colon carcinoma SW620 cells in nude mice.

Schematic representation of experimental protocol A. Gross images of lungs B. or H and E stained photomicrographs C. from Balb/c nude mice administered with 2 × 10⁶ SW620 colon carcinoma cells iv and also co-injected with galectin-3 with or without heparin derivatives E, E3, F, F3, G or G3 (20 mg/kg) iv. Mean tumors per lung D. and lung weight vs tumor number E. are shown for all experimental groups. *p < 0.05 by one-way ANOVA, n = 6 mice per experimental group.