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. 1972 Jul;27(4):480–486. doi: 10.1136/thx.27.4.480

Differential ventilation in unilateral pulmonary artery occlusion

C S Darke 1,2, T W Astin 1,2,1
PMCID: PMC469955  PMID: 5075620

Abstract

A case is reported of complete isolated occlusion of the right pulmonary artery resulting in underperfusion of the right lung; this was confirmed radiographically and at thoracotomy. Bronchospirometry showed that there was a reduction of ventilation to the right lung. When this lung alone was supplied with a carbon dioxide rich mixture there was a shift of ventilation towards the normal pattern with reversion to the initial distribution when air breathing was resumed. Ventilation of the right lung with a low oxygen mixture failed to cause any shift of ventilation. The results confirm that the effects of pulmonary artery occlusion on differential ventilation which have been shown in animals also occur in man and provide further evidence that carbon dioxide can have a bronchodilator action in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Astin T. W., Barer G. R., Shaw J. W., Warren P. The bronchodilator action of carbon dioxide. J Physiol. 1971 May;215(1):33P–34P. [PubMed] [Google Scholar]
  2. CUDKOWICZ L., ABELMANN W. H., LEVINSON G. E., KATZNELSON G., JREISSATY R. M. Bronchial arterial blood flow. Clin Sci. 1960 Feb;19:1–15. [PubMed] [Google Scholar]
  3. DAVISON P. H., ARMITAGE G. H., MCILVEEN D. J. Chronic cor pulmonale due to silent pulmonary embolism. Lancet. 1956 Aug 4;271(6936):224–226. doi: 10.1016/s0140-6736(56)90914-x. [DOI] [PubMed] [Google Scholar]
  4. GAENSLER E. A., CUGELL D. W. Bronchospirometry differential residual volume determination. J Lab Clin Med. 1952 Oct;40(4):558–578. [PubMed] [Google Scholar]
  5. Green M., Widdicombe J. G. The effects of ventilation of dogs with different gas mixtures on airway calibre and lung mechanics. J Physiol. 1966 Oct;186(2):363–381. doi: 10.1113/jphysiol.1966.sp008040. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. LILLINGTON G. A., FOWLER W. S., MILLER R. D., HELMHOLZ H. F., Jr Nitrogen clearance rates of right and left lungs in different positions. J Clin Invest. 1959 Nov;38:2026–2034. doi: 10.1172/JCI103981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. NEWHOUSE M. T., BECKLAKE M. R., MACKLEM P. T., MCGREGOR M. EFFECT OF ALTERATIONS IN END-TIDAL CO2 TENSION ON FLOW RESISTANCE. J Appl Physiol. 1964 Jul;19:745–749. doi: 10.1152/jappl.1964.19.4.745. [DOI] [PubMed] [Google Scholar]
  8. NISELL O. The influence of carbon dioxide on the respiratory movements of isolated perfused lungs. Acta Physiol Scand. 1951 Sep 21;23(4):352–360. doi: 10.1111/j.1748-1716.1951.tb00820.x. [DOI] [PubMed] [Google Scholar]
  9. SADOUL P., FAIVRE G., GILGENKRANTZ J. M., CHERRIER F., SAUNIER C. [Study of respiratory function in post-embolic chronic cor pulmonale]. J Fr Med Chir Thorac. 1962 May-Jun;16:433–446. [PubMed] [Google Scholar]
  10. SEVERINGHAUS J. W., SWENSON E. W., FINLEY T. N., LATEGOLA M. T., WILLIAMS J. Unilateral hypoventilation produced in dogs by occluding one pulmonary artery. J Appl Physiol. 1961 Jan;16:53–60. doi: 10.1152/jappl.1961.16.1.53. [DOI] [PubMed] [Google Scholar]
  11. SWENSON E. W., FINLEY T. N., GUZMAN S. V. Unilateral hypoventilation in man during temporary occlusion of one pulmonary artery. J Clin Invest. 1961 May;40:828–835. doi: 10.1172/JCI104316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Samanek M., Aviado D. M. Interrelationships between pulmonary blood flow and bronchomotor tone: Po2 and Pco2. J Appl Physiol. 1967 Apr;22(4):719–730. doi: 10.1152/jappl.1967.22.4.719. [DOI] [PubMed] [Google Scholar]
  13. Schlozman D. L., Kerby G. R., Ruth W. E. Chronic pulmonary artery thrombosis with features of unilateral hyperlucent lung syndrome. Am J Med. 1971 Apr;50(4):547–551. doi: 10.1016/0002-9343(71)90344-5. [DOI] [PubMed] [Google Scholar]
  14. Shaw J. W. Direct evidence for a dilator action of carbon dioxide in pulmonary vessels when vascular tone is high. J Physiol. 1970 Apr;207(2):75P–76P. [PubMed] [Google Scholar]
  15. Sterling G. M. The mechanism of bronchoconstriction due to hypocapnia in man. Clin Sci. 1968 Apr;34(2):277–285. [PubMed] [Google Scholar]
  16. VENRATH H., ROTTHOFF F., VALENTIN H., BOLT W. Bronchospirographische Untersuchungen bei Durchblutungsstörungen im kleinen Kreislauf. Beitr Klin Tuberk Spezif Tuberkuloseforsch. 1952 Aug 22;107(4):291–294. [PubMed] [Google Scholar]
  17. WICK H. Die Beeinflussung der Tracheobronchial- und Alveolarweite durch lokale Einwirkung des Kohlendioxyds. Arch Int Pharmacodyn Ther. 1952 Jan;88(4):461–472. [PubMed] [Google Scholar]
  18. WILHELMSEN L., SELANDER S., SODERHOLM B., PAULIN S., VARNAUSKAS E., WERKO L. RECURRENT PULMONARY EMBOLISM. Medicine (Baltimore) 1963 Sep;42:335–355. doi: 10.1097/00005792-196309000-00002. [DOI] [PubMed] [Google Scholar]

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