Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke

Tao Yan; Michael Chopp; Jieli Chen

doi:10.1007/s12264-015-1567-z

. 2015 Dec 2;31(6):717–734. doi: 10.1007/s12264-015-1567-z

Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke

Tao Yan ^1,^2,^✉, Michael Chopp ^2,³, Jieli Chen ^2,^4,^✉

PMCID: PMC4699577 NIHMSID: NIHMS747653 PMID: 26625873

Abstract

Stroke, including cerebral ischemia, intracerebral hemorrhage, and subarachnoid hemorrhage, is the leading cause of long-term disability and death worldwide. Animal models have greatly contributed to our understanding of the risk factors and the pathophysiology of stroke, as well as the development of therapeutic strategies for its treatment. Further development and investigation of experimental models, however, are needed to elucidate the pathogenesis of stroke and to enhance and expand novel therapeutic targets. In this article, we provide an overview of the characteristics of commonly-used animal models of stroke and focus on the inflammatory responses to cerebral stroke, which may provide insights into a framework for developing effective therapies for stroke in humans.

Keywords: ischemic stroke, hemorrhagic stroke, animal model, inflammatory cells

Contributor Information

Tao Yan, Email: jieli@neuro.hfh.edu.

Jieli Chen, Email: yantao78@hotmail.com.

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Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke

Tao Yan

Michael Chopp

Jieli Chen

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Experimental animal models and inflammatory cellular changes in cerebral ischemic and hemorrhagic stroke

Tao Yan

Michael Chopp

Jieli Chen

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