Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1972 Nov;27(6):726–728. doi: 10.1136/thx.27.6.726

Effect of disodium cromoglycate (Intal) on sputum protein composition

Sandra Heilpern 1,2,1, A S Rebuck 1,2
PMCID: PMC469971  PMID: 4630567

Abstract

The protein content in the sputum of nine patients with asthma was compared with that in 11 non-asthmatic patients by a method of gel electrophoresis. It was found that the albumin content was significantly higher in the sputum of the asthmatics than of the non-asthmatics (P<0·01). A further 11 asthmatic patients who were taking disodium cromoglycate (Intal) as part of their treatment had sputum albumin levels indistinguishable from the non-asthmatics. When patients with asthma were then studied serially, before and after disodium cromoglycate therapy, the albumin content returned to non-asthmatic levels within two days of starting treatment. It is suggested that disodium cromoglycate has a previously unrecognized action in altering sputum proteins.

Full text

PDF
726

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brogan T. D., Ryley H. C., Allen L., Hutt H. Relation between sputum sol phase composition and diagnosis in chronic chest diseases. Thorax. 1971 Jul;26(4):418–423. doi: 10.1136/thx.26.4.418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cobbin D. M., Elliott F. M., Rebuck A. S. The mucolytic agent bromhexine (bisolvon) in chronic lung disease. A double-blind crossover trial. Aust N Z J Med. 1971 May;1(2):137–140. doi: 10.1111/j.1445-5994.1971.tb02280.x. [DOI] [PubMed] [Google Scholar]
  3. DAVIS B. J. DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. Ann N Y Acad Sci. 1964 Dec 28;121:404–427. doi: 10.1111/j.1749-6632.1964.tb14213.x. [DOI] [PubMed] [Google Scholar]
  4. DENNIS E. G., HORNBROOK M. M., ISHIZAKA K. SERUM PROTEINS IN SPUTUM OF PATIENTS WITH ASTHMA. J Allergy. 1964 Sep-Oct;35:464–471. doi: 10.1016/0021-8707(64)90072-3. [DOI] [PubMed] [Google Scholar]
  5. Davies S. E. Effect of disodium cromoglycate on exercise-induced asthma. Br Med J. 1968 Sep 7;3(5618):593–594. doi: 10.1136/bmj.3.5618.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Havez R., Roussel P., Degand P., Biserte G. Etude des structures fibrillaires de la sécrétion bronchique humaine. Clin Chim Acta. 1967 Aug;17(2):281–295. doi: 10.1016/0009-8981(67)90132-5. [DOI] [PubMed] [Google Scholar]
  7. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  8. Newcomb R. W., DeVald B. Protein concentrations in sputa from asthmatic children. Albumin, lactoferrin, gamma A and gamma G. J Lab Clin Med. 1969 May;73(5):734–743. [PubMed] [Google Scholar]
  9. Orange R. P., Austen K. F. Prospects in asthma therapy: disodium cromoglycate and diethylcarbamazine. N Engl J Med. 1968 Nov 7;279(19):1055–1057. doi: 10.1056/NEJM196811072791912. [DOI] [PubMed] [Google Scholar]
  10. Pepys J., Hargreave F. E., Chan M., McCarthy D. S. Inhibitory effects of disodium cromoglycate on allergen-inhalation tests. Lancet. 1968 Jul 20;2(7560):134–137. doi: 10.1016/s0140-6736(68)90419-4. [DOI] [PubMed] [Google Scholar]
  11. Read J., Rebuck A. S. Steroid-sparing effect of disodium cromoglycate ("Intal") in chronic asthma. Med J Aust. 1969 Mar 15;1(11):566–569. doi: 10.5694/j.1326-5377.1969.tb92293.x. [DOI] [PubMed] [Google Scholar]
  12. Ryley H. C., Brogan T. D. Variation in the composition of sputum in chronic chest diseases. Br J Exp Pathol. 1968 Dec;49(6):625–633. [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES