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. 1973 Mar;28(2):129–135. doi: 10.1136/thx.28.2.129

Pulmonary arterial development during childhood: branching pattern and structure

Alison Hislop 1, Lynne Reid 1
PMCID: PMC470003  PMID: 4731102

Abstract

In lungs from 18 children aged between birth and 11 years the development of the branching pattern and structure of the pulmonary arteries, particularly the intralobular and intra-acinar, has been quantitatively analysed after injection with a radio-opaque medium. Up to 18 months of age as new alveolar ducts appear conventional arterial branches develop within the acinus: supernumerary arteries increase in number up to 8 years as new alveoli form. Both types increase in size with age.

After birth there is an immediate drop in wall thickness of the vessels below 200 μm diameter while the larger vessels take up to 4 months to fall to adult thickness, suggesting two types of response—one dilatation, the other a growth rate change of the muscle cells. During childhood muscle cell formation in the intra-acinar arteries lags behind increase in artery size so that during childhood few muscular arteries are found within the acinus. The functional significance of these changes is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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