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. 1973 Sep;28(5):567–573. doi: 10.1136/thx.28.5.567

Plasma cortisol and the use of hydrocortisone in the treatment of status asthmaticus

Ruth M Cayton 1,2, P Howard 1,2
PMCID: PMC470079  PMID: 4361525

Abstract

Cayton, R. M., and Howard, P. (1973).Thorax, 28, 567-573. Plasma cortisol and the use of hydrocortisone in the treatment of status asthmaticus. Plasma cortisol, intravenous synacthen tests of adrenal function, arterial blood gases, and spirometric tests of respiratory function were measured in patients with bronchial asthma during clinically stable periods and during status asthmaticus. Intravenous hydrocortisone was given in a predetermined manner in an attempt to measure the effective dose for treatment. The presence of adrenal suppression did not influence the severity of the attack nor the amount of hydrocortisone required for treatment. Clinical signs, arterial oxygen tension, forced expiratory volume, forced vital capacity, pulse rate, and blood pressure gave no indication as to which patients would respond to a single injection of aminophylline or require repeated hydrocortisone for days or weeks. The results are discussed in relation to the mechanism of bronchial asthma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Collins J. V., Clark T. J., Harris P. W., Townsend J. Intravenous corticosteroids in treatment of acute bronchial asthma. Lancet. 1970 Nov 21;2(7682):1047–1049. doi: 10.1016/s0140-6736(70)90283-7. [DOI] [PubMed] [Google Scholar]
  2. Connell J. T. Asthmatic deaths. Role of the mast cell. JAMA. 1971 Feb 1;215(5):769–776. doi: 10.1001/jama.215.5.769. [DOI] [PubMed] [Google Scholar]
  3. DUNNILL M. S. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol. 1960 Jan;13:27–33. doi: 10.1136/jcp.13.1.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dunnill M. S., Massarella G. R., Anderson J. A. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax. 1969 Mar;24(2):176–179. doi: 10.1136/thx.24.2.176. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Dwyer J., Lazarus L., Hickie J. B. A study of cortisol metabolism in patients with chronic asthma. Australas Ann Med. 1967 Nov;16(4):297–304. doi: 10.1111/imj.1967.16.4.297. [DOI] [PubMed] [Google Scholar]
  6. MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. McCombs R. P. Diseases due to immunologic reactions in the lungs (first of two parts). N Engl J Med. 1972 Jun 1;286(22):1186–1194. doi: 10.1056/NEJM197206012862205. [DOI] [PubMed] [Google Scholar]
  8. Rebuck A. S., Read J. Assessment and management of severe asthma. Am J Med. 1971 Dec;51(6):788–798. doi: 10.1016/0002-9343(71)90307-x. [DOI] [PubMed] [Google Scholar]
  9. Rees H. A. Management of status asthmaticus. Postgrad Med J. 1967 Apr;43(498):225–233. doi: 10.1136/pgmj.43.498.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Rees H. A., Millar J. S., Donald K. W. A study of the clinical course and arterial blood gas tensions of patients in status asthmaticus. Q J Med. 1968 Oct;37(148):541–561. [PubMed] [Google Scholar]
  11. TREADWELL B. L., SALVAGE O., SEVER E. D., COPEMAN W. S. Pituitary-adrenal function during corticosteroid therapy. Lancet. 1963 Feb 16;1(7277):355–358. doi: 10.1016/s0140-6736(63)91383-7. [DOI] [PubMed] [Google Scholar]
  12. Tai E., Read J. Blood-gas tensions in bronchial asthma. Lancet. 1967 Mar 25;1(7491):644–646. doi: 10.1016/s0140-6736(67)92541-x. [DOI] [PubMed] [Google Scholar]
  13. Walsh S. D., Grant I. W. Corticosteroids in treatment of chronic asthma. Br Med J. 1966 Oct 1;2(5517):796–802. doi: 10.1136/bmj.2.5517.796. [DOI] [PMC free article] [PubMed] [Google Scholar]

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