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. 1973 Nov;28(6):701–708. doi: 10.1136/thx.28.6.701

Pathology of chronic mountain sickness

Javier Arias-Stella 1, Hever Krüger 1, Sixto Recavarren 1
PMCID: PMC470104  PMID: 4787982

Abstract

Arias-Stella, J., Krüger, H., and Recavarren, S. (1973).Thorax, 28, 701-708. Pathology of chronic mountain sickness. Pathological data on chronic mountain sickness are scarce due to the fact that the disease is ameliorated or cured by descent to a low altitude. In this report we describe a case of chronic mountain sickness occurring in a woman of 48 years at Cerro de Pasco (4,300 m above sea level). The necropsy findings are compared with the limited pathological observations reported by others. It is apparent from our findings that in fatal cases the main changes are located within the pulmonary circulation. So far histological studies have been reported only in cases of the secondary form of chronic mountain sickness. The basic pathology of the primary form (Monge's disease) remains to be defined.

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Selected References

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  1. BERGOFSKY E. H., TURINO G. M., FISHMAN A. P. Cardiorespiratory failure in kyphoscoliosis. Medicine (Baltimore) 1959 Sep;38:263–317. doi: 10.1097/00005792-195909000-00004. [DOI] [PubMed] [Google Scholar]
  2. Davies G., Reid L. Effect of scoliosis on growth of alveoli and pulmonary arteries and on right ventricle. Arch Dis Child. 1971 Oct;46(249):623–632. doi: 10.1136/adc.46.249.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. HECHT H. H., KUIDA H., LANGE R. L., HORNE J. L., BROWN A. M. Brisket disease. III. Clinical features and hemodynamic observations in altitude-dependent right heart failure of cattle. Am J Med. 1962 Feb;32:171–183. doi: 10.1016/0002-9343(62)90288-7. [DOI] [PubMed] [Google Scholar]
  4. Hasleton P. S., Heath D., Brewer D. B. Hypertensive pulmonary vascular disease in states of chronic hypoxia. J Pathol Bacteriol. 1968 Apr;95(2):431–440. doi: 10.1002/path.1700950213. [DOI] [PubMed] [Google Scholar]
  5. NAEYE R. L. Kyphoscoliosis and cor pulmonale; a study of the pulmonary vascular bed. Am J Pathol. 1961 May;38:561–573. [PMC free article] [PubMed] [Google Scholar]
  6. Peñaloza D., Sime F. Chronic cor pulmonale due to loss of altitude acclimatization (chronic mountain sickness). Am J Med. 1971 Jun;50(6):728–743. doi: 10.1016/0002-9343(71)90181-1. [DOI] [PubMed] [Google Scholar]
  7. RECAVARREN S., ARIAS-STELLA J. RIGHT VENTRICULAR HYPERTROPHY IN PEOPLE BORN AND LIVING AT HIGH ALTITUDES. Br Heart J. 1964 Nov;26:806–812. doi: 10.1136/hrt.26.6.806. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. RICHTER T., WEST J. R., FISHMAN A. P. The syndrome of alveolar hypoventilation and diminished sensitivity of the respiratory center. N Engl J Med. 1957 Jun 20;256(25):1165–1170. doi: 10.1056/NEJM195706202562501. [DOI] [PubMed] [Google Scholar]
  9. Severinghaus J. W., Bainton C. R., Carcelen A. Respiratory insensitivity to hypoxia in chronically hypoxic man. Respir Physiol. 1966;1(3):308–334. doi: 10.1016/0034-5687(66)90049-1. [DOI] [PubMed] [Google Scholar]
  10. Sorensen S. C., Severinghaus J. W. Irreversible respiratory insensitivity to acute hypoxia in man born at high altitude. J Appl Physiol. 1968 Sep;25(3):217–220. doi: 10.1152/jappl.1968.25.3.217. [DOI] [PubMed] [Google Scholar]

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