Table 1. Candidate gene expression levels predicting behavior.
| Mouse HS open field LOD scores (additive model) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chr | Trait | QTL C.I. (Mb) | eQTL | PhQTL pos | Gene P-value | NEO leo.nb score | Model P-value | Marker | Latency | Total activity | Time in center | Marker |
| 2 | Time in center zone trial 2 | 45.5–51.9 | SFRP4 | 2@426 | 0.04 | NA | NA | rs2709114 | — | — | — | rs13481716 |
| 2 | Time in center zone trial 2 | 45.5–51.9 | STK17A | 2@426 | 0.004 | NA | NA | rs1181601 | — | — | — | rs6253368 |
| 3 | Minimum total movement | 25.1–27 | RSPH9 | 3@277 | 0.03 | 0.823 | 5.48E-06 | rs3778493 | 4.7 | 7.8 | — | UT_17_45.56 |
| 3 | Minimum total movement | 25.1–27 | C1orf107/DIEXF | 3@277 | 0.003 | 0.368 | 0.804 | rs7549523 | — | — | — | rs3684501 |
| 8 | Total velocity average | 23.9–26.6 | RABGGTB | 8@194.0 | 0.05 | NA | NA | rs7555627 | — | — | — | rs3656403 |
| 10 | Total velocity average | 4.3–6.8 | ADAM10 | 10@101 | 0.03 | 0.44 | 0.396 | rs2242321 | — | — | — | rs13480265 |
| 10 | Total velocity average | 4.3–6.8 | APBA2 | 10@101 | 0.01 | 0.0421 | 0.0719 | rs7680321 | — | 7.7 | — | rs3717846 |
| 10 | Total velocity trial 1 | 14.4–17.4 | LOC770352 | 10@185.0 | 0.002 | 0.943 | 0.687 | rs1480617 | — | — | 4.5 | rs13476065 |
| 10 | Total movement average | 14.4–17.4 | LOC770352 | 10@185.0 | 0.0002 | 1.07 | 0.956 | rs1480617 | — | — | 4.5 | rs13476065 |
| 10 | Minimum total movement | 14.4–17.4 | LOC770352 | 10@182.0 | 0.003 | 0.874 | 0.925 | rs1480617 | — | — | 4.5 | rs13476065 |
| 10 | Total movement trial 2 | 7.6–15.0 | LOC770352 | 10@64.0 | 0.0012 | 0.747 | 0.878 | rs1480617 | — | — | 4.5 | rs13476065 |
| 10 | Maximum total movement | 14.4–17.4 | LOC770352 | 10@185.0 | 0.0003 | 1.13 | 0.985 | rs1480617 | — | — | 4.5 | rs13476065 |
| 10 | Total velocity trial 1 | 4.3–6.8 | APBA2 | 10@99.0 | 0.004 | 0.977 | 0.131 | rs7680321 | — | 7.7 | — | rs3717846 |
| 10 | Total velocity trial 1 | 4.3–6.8 | ADAM10 | 10@99.0 | 0.04 | 0.515 | 0.37 | rs2242321 | — | — | — | rs13480265 |
| 10 | Total movement trial 1 | 4.3–6.8 | LOC770352 | 10@99.0 | 0.008 | 0.815 | 0.852 | rs7680321 | — | — | 4.5 | rs13476065 |
| 10 | Total movement average | 4.3–6.8 | APBA2 | 10@99.0 | 0.02 | −0.966 | 0.0002 | rs7680321 | — | 7.7 | — | rs3717846 |
| 13 | Total velocity trial 2 | 1.5–4.1 | GABRB2 | 13@32.0 | 0.0014 | NA | NA | rs4302629 | 5.1 | 5.1 | — | rs6225242 |
| 17 | Total velocity average | 1–2.5 | SLC31A1 | 17@1 | 0.004 | NA | NA | rs786978 | — | — | — | rs3690581 |
| 17 | Total velocity trial 1 | 1–2.5 | SLC31A1 | 17@1 | 0.003 | NA | NA | rs786978 | — | — | — | rs3690581 |
Chromosome (Chr) and QTL confidence interval are given for the trait that each eQTL significantly correlated with. The phenotypic QTL position (PhQTL pos) is also given in centimorgans. The P-value of the correlation, after Bonferroni correction, is also provided (Gene P-value). The causality modeling scores are also indicated for each gene, as are the WTCCC P-values for each gene region. The association of each gene with the mouse HS cross is also given, with the LOD scores of the gene location for each of the three different open field tests provided.