Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1974 Mar;29(2):237–244. doi: 10.1136/thx.29.2.237

Lower-zone emphysema in young patients without α1-antitrypsin deficiency

Nestor A Martelli 1, Ernesto Goldman 1, Aquiles J Roncoroni 1
PMCID: PMC470136  PMID: 4545502

Abstract

Martelli, N. A., Goldman, E., and Roncoroni, A. J. (1974).Thorax, 29, 237-244. Lowerzone emphysema in young patients without α1-antitrypsin deficiency. Three young patients with radiographic pulmonary emphysema predominantly in the lower zones are reported. The clinical and physiological features were those observed in severe pulmonary emphysema. Predominance of the main lesions in the lower zones was confirmed in two cases by selective pulmonary angiography. One of the patients died and extensive panlobular emphysema was found at necropsy. Although the similarities between our patients and those with emphysema and α1-antitrypsin deficiency were remarkable, the latter condition was ruled out.

Full text

PDF
237

Images in this article

238Image
on p.238
239Image
on p.239
240Image
on p.240
241Image
on p.241
242Image
on p.242
243Image
on p.243

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BENTIVOGLIO L. G., BEEREL F., STEWART P. B., BRYAN A. C., BALL W. C., Jr, BATES D. V. STUDIES OF REGIONAL VENTILATION AND PERFUSION IN PULMONARY EMPHYSEMA USING XENON133. Am Rev Respir Dis. 1963 Sep;88:315–329. doi: 10.1164/arrd.1963.88.3P1.315. [DOI] [PubMed] [Google Scholar]
  2. CARASSO B., MAHEUX P., GREGOIRE F. Progressive bilateral bullous emphysema, with special reference to pulmonary function tests. Am Rev Tuberc. 1955 Jun;71(6):867–876. doi: 10.1164/artpd.1955.71.6.867. [DOI] [PubMed] [Google Scholar]
  3. DUBOIS A. B., BOTELHO S. Y., BEDELL G. N., MARSHALL R., COMROE J. H., Jr A rapid plethysmographic method for measuring thoracic gas volume: a comparison with a nitrogen washout method for measuring functional residual capacity in normal subjects. J Clin Invest. 1956 Mar;35(3):322–326. doi: 10.1172/JCI103281. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. DUBOIS A. B., BOTELHO S. Y., COMROE J. H., Jr A new method for measuring airway resistance in man using a body plethysmograph: values in normal subjects and in patients with respiratory disease. J Clin Invest. 1956 Mar;35(3):327–335. doi: 10.1172/JCI103282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Fagerhol M. K., Laurell C. B. The Pi system-inherited variants of serum alpha 1-antitrypsin. Prog Med Genet. 1970;7:96–111. [PubMed] [Google Scholar]
  6. Guenter C. A., Welch M. H., Russell T. R., Hyde R. M., Hammarsten J. F. The pattern of lung disease associated with alpha antitrypsin deficiency. Arch Intern Med. 1968 Sep;122(3):254–257. [PubMed] [Google Scholar]
  7. HOMER G. M., KATCHMAN B. J., ZIPF R. E. A SPECTROPHOTOMETRIC METHOD FOR MEASURING SERUM TRYPSIN INHIBITOR CAPACITY. Clin Chem. 1963 Aug;12:428–437. [PubMed] [Google Scholar]
  8. Hepper N. G., Black L. F., Gleich G. J., Kueppers F. The prevalence of alpha 1-antitrypsin deficiency in selected groups of patients with chronic obstructive lung disease. Mayo Clin Proc. 1969 Oct;44(10):697–710. [PubMed] [Google Scholar]
  9. Hutchison D. C., Barter C. E., Cook P. J., Laws J. W., Martelli N. A., Hugh-Jones P. Severe pulmonary emphysema. A comparison of patients with and without 1 -antitrypsin deficiency. Q J Med. 1972 Jul;41(163):301–315. [PubMed] [Google Scholar]
  10. Hutchison D. C., Cook P. J., Barter C. E., Harris H., Hugh-Jones P. Pulmonary emphysema and alpha 1-antitrypsin deficiency. Br Med J. 1971 Mar 27;1(5751):689–694. doi: 10.1136/bmj.1.5751.689. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jones M. C., Thomas G. O. Alpha antitrypsin deficiency and pulmonary emphysema. Thorax. 1971 Nov;26(6):652–662. doi: 10.1136/thx.26.6.652. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lieberman J., Gaidulis L., Garoutte B., Mittman C. Identification and characteristics of the common alpha 1 -antitrypsin phenotypes. Chest. 1972 Nov;62(5):557–564. doi: 10.1378/chest.62.5.557. [DOI] [PubMed] [Google Scholar]
  13. Lieberman J. Heterozygous and homozygous alpha-antitrypsin deficiency in patients with pulmonary emphysema. N Engl J Med. 1969 Aug 7;281(6):279–284. doi: 10.1056/NEJM196908072810601. [DOI] [PubMed] [Google Scholar]
  14. MILIC-EMILI J., MEAD J., TURNER J. M., GLAUSER E. M. IMPROVED TECHNIQUE FOR ESTIMATING PLEURAL PRESSURE FROM ESOPHAGEAL BALLOONS. J Appl Physiol. 1964 Mar;19:207–211. doi: 10.1152/jappl.1964.19.2.207. [DOI] [PubMed] [Google Scholar]
  15. REID L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax. 1960 Jun;15:132–141. doi: 10.1136/thx.15.2.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SEEBOHM P. M., BEDELL G. N. Primary pulmonary emphysema in young adults. Am Rev Respir Dis. 1963 Jan;87:41–46. doi: 10.1164/arrd.1963.87.1.41. [DOI] [PubMed] [Google Scholar]
  17. Stevens P. M., Hnilica V. S., Johnson P. C., Bell R. L. Pathophysiology of hereditary emphysema. Ann Intern Med. 1971 May;74(5):672–680. doi: 10.7326/0003-4819-74-5-672. [DOI] [PubMed] [Google Scholar]
  18. Talamo R. C., Allen J. D., Kahan M. G., Auste K. F. Hereditary alpha-1-antitrypsin deficiency. N Engl J Med. 1968 Feb 15;278(7):345–351. doi: 10.1056/NEJM196802152780701. [DOI] [PubMed] [Google Scholar]
  19. Tarkoff M. P., Kueppers F., Miller W. F. Pulmonary emphysema and alpha 1-antitrypsin deficiency. Am J Med. 1968 Aug;45(2):220–228. doi: 10.1016/0002-9343(68)90040-5. [DOI] [PubMed] [Google Scholar]
  20. Turner J. M., Mead J., Wohl M. E. Elasticity of human lungs in relation to age. J Appl Physiol. 1968 Dec;25(6):664–671. doi: 10.1152/jappl.1968.25.6.664. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES