In Table 2, the AITL fold-change value column was inadvertently duplicated into the PTCL-NOS fold-change column. Please see the corrected Table 2 here.
Table 2. Genes significantly up- or down-regulated across all mature T-cell lymphoma subtypes as compared with healthy CD4+ and CD8+ T-cell controls.
| Gene Name | Symbol | Chromosomal Location | AITL Fold-Change | ALCL Fold-Change | ATLL Fold-Change | HSTL Fold-Change | PTCL-NOS Fold-Change |
|---|---|---|---|---|---|---|---|
| Caveolin-1 | CAV1 | 7q31.1 | 16.33 | 12.52 | 38.17 | 34.41 | 17.03 |
| Cyclin B2 | CCNB2 | 15q22.2 | 7.55 | 8.93 | 13.99 | 9.65 | 10.81 |
| Thy-1 cell surface antigen | THY1 | 11q23.3 | 13.65 | 12.98 | 9.46 | 2.46 | 9.88 |
| Tumor necrosis factor receptor superfamily member 21 | TNFRSF21 | 6p21.1 | 6.38 | 6.27 | 5.34 | 9.30 | 8.02 |
| Enabled homolog | ENAH | 1q42.12 | 5.62 | 5.36 | 2.52 | 22.63 | 5.32 |
| Presenilin 2 | PSEN2 | 1q42.13 | 2.94 | 4.77 | 2.26 | 3.39 | 3.09 |
| 3g molecule, gamma (CD3-TCR complex) | CD3G | 11q23 | -3.01 | -6.81 | -1.65 | -2.02 | -2.53 |
| Tumor necrosis factor receptor superfamily member 14 | TNFRSF14 | 1p36.32 | -1.49 | -1.58 | -1.69 | -1.99 | -1.47 |
| RPTOR independent companion of MTOR, complex 2 | RICTOR | 5p13.1 | -2.42 | -4.36 | -1.75 | -2.25 | -2.03 |
| Linker for activation of T-cells | LAT | 16p11.2 | -2.91 | -3.61 | -1.92 | -3.76 | -2.15 |
| CD5 molecule | CD5 | 11q13 | -4.12 | -6.55 | -2.10 | -17.27 | -3.98 |
| Interleukin 23, alpha subunit p19 | IL23A | 12q13.3 | -3.26 | -3.50 | -2.23 | -4.51 | -3.23 |
| IL2-inducible T-cell kinase | ITK | 5q31-q32 | -3.67 | -10.78 | -2.36 | -2.70 | -3.82 |
| Signal transducer and activator of transcription 5A | STAT5A | 17q11.2 | -2.14 | -2.11 | -2.50 | -2.63 | -2.27 |
| TSC22 domain family, member 3 | TSC22D3 | Xq22.3 | -5.66 | -6.63 | -2.56 | -4.07 | -4.99 |
| Ubiquitin-associated and SH3 domain-containing protein A | UBASH3A | 21q22.3 | -2.43 | -4.27 | -2.86 | -6.97 | -2.46 |
| Protein kinase C theta | PRKCQ | 10p15 | -2.98 | -8.26 | -3.58 | -2.92 | -3.86 |
| Forkhead box P1 | FOXP1 | 3p14.1 | -4.90 | -3.96 | -3.69 | -3.40 | -3.84 |
| Phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | PAG1 | 8q21.13 | -3.81 | -2.32 | -4.30 | -3.69 | -2.63 |
| B-cell CLL/lymphoma 10 | BCL10 | 1p22 | -4.96 | -7.82 | -6.54 | -7.15 | -6.26 |
| Phosphodiesterase 4B, cAMP-specific | PDE4B | 1p31 | -4.21 | -3.55 | -7.44 | -3.42 | -2.45 |
AITL, angioimmunoblastic T-cell lymphoma; ALCL, anaplastic large cell lymphoma; ATLL, adult T-cell leukemia/lymphoma; HSTL, hepatosplenic T-cell lymphoma; PTCL-NOS, peripheral T-cell lymphoma, not otherwise specified
Reference
- 1.Herek TA, Shew TD, Spurgin HN, Cutucache CE (2015) Conserved Molecular Underpinnings and Characterization of a Role for Caveolin-1 in the Tumor Microenvironment of Mature T-Cell Lymphomas. PLoS ONE 10(11): e0142682 doi:10.1371/journal.pone.0142682 [DOI] [PMC free article] [PubMed] [Google Scholar]