Abstract
Siegler, D. I. M. and Citron, K. M. (1974).Thorax, 29, 313-316. Serum and parotid salivary IgA in chronic bronchitis and asthma. It has been suggested that immunoglobulin A (IgA) deficiency may be an important predisposing factor to infection in chronic bronchitis and that this occurs more often in extrinsic asthmatics than in normal subjects. These claims have been investigated by measurement of IgA in stimulated parotid saliva and serum in chronic bronchitics and asthmatics. Salivary and serum IgA levels in 84 chronic bronchitics could not be correlated with sputum purulence, the degree of ventilatory impairment, radiographic evidence of emphysema or the smoking history. Serum IgA was low in 6% and salivary IgA was normal in all cases. IgA levels measured in both serum and saliva in 50 asthmatics showed no correlation with the number of positive skin tests or other evidence of atopy. Serum IgA was low in 8% and salivary IgA was normal in all cases.
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- Alford R. H. Effects of chronic bronchopulmonary disease and aging on human nasal secretion IgA concentrations. J Immunol. 1968 Nov;101(5):984–988. [PubMed] [Google Scholar]
- CHODIRKER W. B., TOMASI T. B., Jr GAMMA-GLOBULINS: QUANTITATIVE RELATIONSHIPS IN HUMAN SERUM AND NONVASCULAR FLUIDS. Science. 1963 Nov 22;142(3595):1080–1081. doi: 10.1126/science.142.3595.1080. [DOI] [PubMed] [Google Scholar]
- CURBY W. A. Device for collection of human parotid saliva. J Lab Clin Med. 1953 Mar;41(3):493–496. [PubMed] [Google Scholar]
- Falk G. A., Okinaka A. J., Siskind G. W. Immunoglobulins in the bronchial washings of patients with chronic obstructive pulmonary disease. Am Rev Respir Dis. 1972 Jan;105(1):14–21. doi: 10.1164/arrd.1972.105.1.14. [DOI] [PubMed] [Google Scholar]
- Hobday J. D., Cake M., Turner K. J. A comparison of the immunoglobulins IgA, IgG and IgE in nasal secretions from normal and asthmatic children. Clin Exp Immunol. 1971 Nov;9(5):577–583. [PMC free article] [PubMed] [Google Scholar]
- Kaufman H. S., Hobbs J. R. Immunoglobulin deficiencies in an atopic population. Lancet. 1970 Nov 21;2(7682):1061–1063. doi: 10.1016/s0140-6736(70)90288-6. [DOI] [PubMed] [Google Scholar]
- Lewis D. M., Lapp N. L., Burrell R. Quantitation of secretory immunoglobulin A in chronic pulmonary disease. Am Rev Respir Dis. 1970 Jan;101(1):55–61. doi: 10.1164/arrd.1970.101.1.55. [DOI] [PubMed] [Google Scholar]
- Medici T. C., Buergi H. The role of immunoglobulin A in endogenous bronchial defense mechanisms in chronic bronchitis. Am Rev Respir Dis. 1971 Jun;103(6):784–791. doi: 10.1164/arrd.1971.103.6.784. [DOI] [PubMed] [Google Scholar]
- Oon C. H., Lee J. A controlled quantitative study of parotid salivary secretory IgA-globulin in normal adults. J Immunol Methods. 1972 Nov;2(1):45–48. doi: 10.1016/0022-1759(72)90016-6. [DOI] [PubMed] [Google Scholar]
- Salvaggio J., Lopez M., Arquembourg P., Waldman R., Sly M. Salivary, nasal wash, and sputum IgA concentrations in atopic and nonatopic individuals. J Allergy Clin Immunol. 1973 Jun;51(6):335–343. doi: 10.1016/0091-6749(73)90072-9. [DOI] [PubMed] [Google Scholar]
- Taylor B., Norman A. P., Orgel H. A., Stokes C. R., Turner M. W., Soothill J. F. Transient IgA deficiency and pathogenesis of infantile atopy. Lancet. 1973 Jul 21;2(7821):111–113. doi: 10.1016/s0140-6736(73)93060-2. [DOI] [PubMed] [Google Scholar]
- Tomasi T. B., Jr, Bienenstock J. Secretory immunoglobulins. Adv Immunol. 1968;9:1–96. doi: 10.1016/s0065-2776(08)60441-1. [DOI] [PubMed] [Google Scholar]