There are errors in the ninth, tenth and eleventh sentences of the Abstract. The correct sentences are: Individual genotyping of KLF7 rs2284932 revealed that the frequency of the minor C allele was significantly increased (P = 0.00062, Pc = 0.003, OR = 2.98, 95%CI = 1.58–5.65) in group A. The minor T allele of rs4473559 in FRMD4 demonstrated a significant association in the A group (P = 0.00015, OR = 3.38, 95%CI = 1.77–6.45). In the LOC101928923 gene, the frequency of the minor T allele of rs4379306 was significantly decreased in group A in both TaqMan and GWAS analyses. Lastly, the minor C allele of MPPED2 rs514644 carried a significantly increased risk of complications.
There is an error in the third sentence of the Genetic Analysis section of the Results. The correct sentence is: The results for strong signals (P<0.0001) are shown in Table 1. There are also errors in the penultimate sentence of this section. The correct sentence is: In the LOC101928923 gene, the frequency of the minor T allele of rs4379306 was significantly decreased (P = 0.011, OR = 0.43) in both TaqMan and GWAS analyses in the A group (Table 5).
There is an error in Table 3. The P value for rs2284932 should be CC+TC/TT. Please see the corrected Table 3 here.
Table 3. Association analysis of single nucleotide polymorphisms in the KLF7 gene.
| dbSNP ID | Chrom. location | Typing method | Alleles | Frequency (%) | P value | Pc value | OR (95% CI) | |||
|---|---|---|---|---|---|---|---|---|---|---|
| A group | B group | |||||||||
| rs2287505 | 207655331 | GWAS | C>A | A | 0.027 | 2.74(1.09–6.90) | ||||
| rs1263615 | 207667483 | TaqMan | A>G | A | 74.0 | 68.6 | G | 0.758 | 3.032 | 1.10(0.61–1.96) |
| G | 26.0 | 31.4 | GG+GA/AA | 0.567 | 2.268 | 1.26(0.57–2.81) | ||||
| rs768090 | 207711824 | TaqMan | A>T | A | 74.0 | 83.3 | T | 0.091 | 0.364 | 1.80(0.91–3.57) |
| T | 26.0 | 16.7 | TT+TA/AA | 0.047 | 0.188 | 2.28(1.01–5.16) | ||||
| rs10195536 | 207715065 | GWAS | T>A | A | 0.016 | 3.79(1.21–11.92) | ||||
| rs2284932 | 207720754 | TaqMan | T>C | T | 90.0 | 95.1 | C | 0.00062 | 0.003 | 2.98(1.58–5.65) |
| C | 10.0 | 4.9 | CC+TC/TT | 0.00037 | 0.002 | 4.37(1.90–10.02) | ||||
| GWAS | C | 0.0000021 | 4.35(2.32–8.16) | |||||||
| rs12466923 | 207721800 | TaqMan | A>C | A | 60.0 | 81.4 | C | 0.039 | 0.156 | 2.16 (1.03–4.54) |
| C | 40.0 | 18.6 | CC+AC/AA | 0.0093 | 0.037 | 3.10(1.30–7.38) | ||||
A group: with lachrymal/salivary gland lesions, B group: without lachrymal/salivary gland lesions, dbSNP ID: SNP database identification, Chrom: chromosome, Pc: corrected P
Reference
- 1.Oguchi T, Ota M, Ito T, Hamano H, Arakura N, Katsuyama Y, et al. (2015) Investigation of Susceptibility Genes Triggering Lachrymal/Salivary Gland Lesion Complications in Japanese Patients with Type 1 Autoimmune Pancreatitis. PLoS ONE 10(5): e0127078 doi: 10.1371/journal.pone.0127078 [DOI] [PMC free article] [PubMed] [Google Scholar]