Abstract
Critchley, M., Testa, H. J., and Stretton, T. B. (1974).Thorax, 29, 421-424. Combined use of 99mtechnetium-labelled macroaggregates of albumin and 75selenium-selenomethionine in the diagnosis of lung cancer. A two-stage isotope technique has been used in 30 patients with radiographic evidence of circumscribed pulmonary lesions in an attempt to establish the nature of the underlying pathological process. The test was carried out as a `blind' procedure without knowledge of the findings of investigations other than the plain chest radiograph. An initial scan was performed with 99mtechnetium-labelled macroaggregated albumin. The view showing the lesion most clearly was selected and a second scan was obtained after an intravenous injection of 75Se-selenomethionine. Scans were interpreted by comparison of the `cold area' on the technetium scan with the corresponding area on the selenomethionine scan. Accumulation of 75Se-selenomethionine at the site corresponding to the lesion is described as a positive result and absence of accumulation as negative. The findings suggest that there is selective uptake of 75Se-selenomethionine by primary bronchogenic carcinoma; in the few patients with secondary carcinomas and non-malignant disease investigated so far, the lesion has failed to concentrate 75Se-selenomethionine.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Awwad H. K., Adelstein S. J., Potchen E. J., Dealy J. B., Jr The interconversion and reutilization of injected 75-Se-selenomethionine in the rat. J Biol Chem. 1967 Feb 10;242(3):492–500. [PubMed] [Google Scholar]
- Cavalieri R. R., Scott K. G., Sairenji E. Selenite (75Se) as a tumor-localizing agent in man. J Nucl Med. 1966 Mar;7(3):197–208. [PubMed] [Google Scholar]
- Eddleston A. L., Rake M. O., Pagaltsos A. P., Osborn S. B., Williams R. 75se-selenomethionine in the scintiscan diignosis of primary hepatocellular carcinoma. Gut. 1971 Apr;12(4):245–249. doi: 10.1136/gut.12.4.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Higasi T., Nakayama Y., Murata A., Sugiyama M., Nakamura K. Clinical evaluation of 67 Ga-citrate scanning. J Nucl Med. 1972 Mar;13(3):196–201. [PubMed] [Google Scholar]