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. 1974 Sep;29(5):574–577. doi: 10.1136/thx.29.5.574

Changes in specific airways conductance and forced expiratory volume in one second after a bronchodilator in normal subjects and patients with airways obstruction

C Skinner 1, K N V Palmer 1
PMCID: PMC470202  PMID: 4428459

Abstract

Skinner, C. and Palmer, K.N.V. (1974).Thorax, 29, 574-577. Changes in specific airways conductance and forced expiratory volume in one second after a bronchodilator in normal subjects and patients with airways obstruction. Specific conductance (SGaw) and the forced expiratory volume in one second (FEV1) were measured in 10 normal, 10 asthmatic, and 10 obstructive bronchitic subjects before and after aerosol salbutamol. Mean SGaw increased by 37% in normals, by 109% in asthmatics, and by 38% in obstructive bronchitics. Mean FEV1 increased by 2% in normals, by 32% in asthmatics, and by 12% in obstructive bronchitics. SGaw appears to be a more sensitive indicator than FEV1 of changes in airways calibre following a bronchodilator drug in normal subjects, but FEV1 is as good an indicator of these changes as SGaw in patients with airways obstruction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Astin T. W. Reversibility of airways obstruction in chronic bronchitis. Clin Sci. 1972 Jun;42(6):725–733. doi: 10.1042/cs0420725. [DOI] [PubMed] [Google Scholar]
  2. Bouhuys A., Van de Woestijne K. P. Mechanical consequences of airway smooth muscle relaxation. J Appl Physiol. 1971 May;30(5):670–676. doi: 10.1152/jappl.1971.30.5.670. [DOI] [PubMed] [Google Scholar]
  3. Cohen B. M. Airways flow resistance as a measure of the efficacy of inhalants in clinical drug trials. Helv Med Acta. 1969 Mar;34(6):455–467. [PubMed] [Google Scholar]
  4. Feinsilver O. Airway resistance as an index of effectiveness of bronchodilating drugs. J Allergy. 1966 Oct;38(4):195–207. doi: 10.1016/0021-8707(66)90053-0. [DOI] [PubMed] [Google Scholar]
  5. Guyatt A. R., Alpers J. H. Factors affecting airways conductance: a study of 752 working men. J Appl Physiol. 1968 Mar;24(3):310–316. doi: 10.1152/jappl.1968.24.3.310. [DOI] [PubMed] [Google Scholar]
  6. LLOYD T. C., Jr, WRIGHT G. W. Evaluation of methods used in detecting changes of airway resistance in man. Am Rev Respir Dis. 1963 Apr;87:529–537. doi: 10.1164/arrd.1963.87.4.529. [DOI] [PubMed] [Google Scholar]
  7. McFadden E. R., Jr, Newton-Howes J. Acute effects of inhaled isoproterenol on the mechanical characteristics of the lungs in normal man. J Clin Invest. 1970 Apr;49(4):779–790. doi: 10.1172/JCI106291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pride N. B. The assessment of airflow obstruction. Role of measurements of airways resistance and of tests of forced expiration. Br J Dis Chest. 1971 Jul;65:135–169. doi: 10.1016/0007-0971(71)90018-0. [DOI] [PubMed] [Google Scholar]

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