Abstract
Maranetra, N. and Pain, M. C. F. (1974). Thorax, 29, 578-581. Ventilatory drive and ventilatory response during rebreathing. The increase in inspiratory airway pressure generated against a transiently occluded airway during rebreathing is proposed as a simple index of ventilatory drive (ΔP/ΔPco2). A study of this index in 12 normal subjects and 50 patients with chronic airways obstruction demonstrated no significant difference between normals and patients in ΔP/ΔPco2 despite an overall reduction in the ventilatory response to carbon dioxide (ΔV̇e/ΔPco2) in the patients. A significant association was demonstrated between the ventilatory response to carbon dioxide, ΔP/ΔPco2 and the degree of airways obstruction. Patients with a low ΔP/ΔPco2 showed greater hypoxaemia, hypercapnia, and polycythaemia than patients with a higher ΔP/ΔPco2 for the same degree of airways obstruction.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Lourenço R. V., Miranda J. M. Drive and performance of the ventilatory apparatus in chronic obstructive lung disease. N Engl J Med. 1968 Jul 11;279(2):53–59. doi: 10.1056/NEJM196807112790201. [DOI] [PubMed] [Google Scholar]
- Read D. J. A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med. 1967 Feb;16(1):20–32. doi: 10.1111/imj.1967.16.1.20. [DOI] [PubMed] [Google Scholar]
- Rebuck A. S., Read J. Patterns of ventilatory response to carbon dioxide during recovery from severe asthma. Clin Sci. 1971 Jul;41(1):13–21. doi: 10.1042/cs0410013. [DOI] [PubMed] [Google Scholar]