Skip to main content
Thorax logoLink to Thorax
. 1975 Aug;30(4):426–429. doi: 10.1136/thx.30.4.426

Tetracosactrin for the management of asthmatic patients after long-term corticosteroids.

P Hugh-Jones, R S Pearson, M Booth
PMCID: PMC470303  PMID: 170703

Abstract

Thirty-five of 41 asthmatic patients, who had been taking oral corticosteroids regularly for between one and 12 years, recovered their adrenal function after courses of depot tetracosactrin, even those with apparently complete adrenal suppression. They all showed benefit by transfer to depot tetracosactrin, though steroid withdrawal symptoms could be troublesome. Skin pigmentation in three, and two severe reactions to tetracosactrin were encountered. We believe that it is advisable to give depot tetracosactrin when converting severe asthmatics to the use of beclomethasone dipropionate aerosols who have previously been treated by long-term steroids with consequent adrenal suppression.

Full text

PDF
426

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON J. P. Prolonged steroid therapy in childhood asthma. Am J Dis Child. 1960 Sep;100:341–352. doi: 10.1001/archpedi.1960.04020040343006. [DOI] [PubMed] [Google Scholar]
  2. Brown H. M., Storey G. Beclomethasone dipropionate steriod aerosol in treatment of perennial allergic asthma in children. Br Med J. 1973 Jul 21;3(5872):161–164. doi: 10.1136/bmj.3.5872.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chatterjee S. S., Ross A. E., Carroll K., Harris D. M., Butler A. G. Respiratory function on asthmatic patients using beclomethasone dipropionate administered by pressurised aerosol. Curr Med Res Opin. 1972;1(3):173–181. doi: 10.1185/03007997209111163. [DOI] [PubMed] [Google Scholar]
  4. Dwyer J., Lazarus L., Hickie J. B. A study of cortisol metabolism in patients with chronic asthma. Australas Ann Med. 1967 Nov;16(4):297–304. doi: 10.1111/imj.1967.16.4.297. [DOI] [PubMed] [Google Scholar]
  5. Gaddie J., Reid I. W., Skinner C., Petrie G. R., Sinclair D. J., Palmer K. N. Aerosol beclomethasone dipropionate in chronic bronchial asthma. Lancet. 1973 Mar 31;1(7805):691–693. doi: 10.1016/s0140-6736(73)91479-7. [DOI] [PubMed] [Google Scholar]
  6. Galvão-Teles A., Burke C. W., Fraser T. R. Adrenal function tested with tetracosactrin depot. Lancet. 1971 Mar 20;1(7699):557–560. doi: 10.1016/s0140-6736(71)91160-3. [DOI] [PubMed] [Google Scholar]
  7. Glass D., Morley J., Williams T. J., Daly J. R. Allergy to tetracosactrin-depot. Lancet. 1971 Mar 13;1(7698):547–548. doi: 10.1016/s0140-6736(71)91147-0. [DOI] [PubMed] [Google Scholar]
  8. Jensen N. E., Sneddon I. Allergic intolerance to tetracosactrin. Br Med J. 1969 May 10;2(5653):383–384. doi: 10.1136/bmj.2.5653.383-e. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Livanou T., Ferriman D., James V. H. Recovery of hypothalamo-pituitary-adrenal function after corticosteroid therapy. Lancet. 1967 Oct 21;2(7521):856–859. doi: 10.1016/s0140-6736(67)92592-5. [DOI] [PubMed] [Google Scholar]
  10. Maberly D. J., Gibson G. J., Butler A. G. Recovery of adrenal function after substitution of beclomethasone dipropionate for oral corticosteroids. Br Med J. 1973 Mar 31;1(5856):778–779. doi: 10.1136/bmj.1.5856.778. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Malone D. N., Grant I. W., Percy-Robb I. W. Hypothalamo-pituitary-adrenal function in asthmatic patients receiving long-term corticosteroid therapy. Lancet. 1970 Oct 10;2(7676):733–735. doi: 10.1016/s0140-6736(70)90217-5. [DOI] [PubMed] [Google Scholar]
  12. Maunsell K., Pearson R. S., Livingstone J. L. Long-term corticosteroid treatment of asthma. Br Med J. 1968 Mar 16;1(5593):661–665. doi: 10.1136/bmj.1.5593.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nelson J. K., Neill D. W., Montgomery D. A., MacKay J. S., Sheridan B., Weaver J. A. Synacthen Depot--Adrenal response in normal subjects and corticotrophin-treated patients. Br Med J. 1968 Mar 2;1(5591):557–558. doi: 10.1136/bmj.1.5591.557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Pines A. Beclomethasone dipropionate used as an aerosol in the treatment of asthma. Practitioner. 1973 Jul;211(261):86–90. [PubMed] [Google Scholar]
  15. Smith A. P., Booth M., Davey A. J. A controlled trial of beclomethasone dipropionate for asthma. Br J Dis Chest. 1973 Jul;67(3):208–214. doi: 10.1016/0007-0971(73)90055-7. [DOI] [PubMed] [Google Scholar]
  16. Walsh S. D., Grant I. W. Corticosteroids in treatment of chronic asthma. Br Med J. 1966 Oct 1;2(5517):796–802. doi: 10.1136/bmj.2.5517.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Wynn V. The assessment of hypothalamic-pituitary-adrenocortical function in man. Proc R Soc Med. 1967 Sep;60(9):909–910. [PMC free article] [PubMed] [Google Scholar]
  18. el-Shaboury A. H. Assessment of long-acting synthetic corticotrophin in hypersensitive asthmatics and normal subjects. Br Med J. 1968 Sep 14;3(5619):653–655. doi: 10.1136/bmj.3.5619.653. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES