Abstract
Nocturnal and early morning breathlessness is a common and important symptom in asthmatic patients. Six patients in whom these symptoms were a major clinical problem have been studied by serial measurements of peak expiratory flow rate (PEFR) and plasma corticosteroids over two 24-hour periods. Although PEFR and plasma corticosteroids are lowest during the night or early morning, preventing the nocturnal fall in plasma corticosteroids by cortisol infusion did not prevent the fall in PEFR in five out of the six patients. The circadian rhythm of corticosteroid secretion does not appear to be the main cause of nocturnal and early morning asthma.
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- BOUHUYS A. Effect of posture in experimental asthma in man. Am J Med. 1963 Apr;34:470–476. doi: 10.1016/0002-9343(63)90069-x. [DOI] [PubMed] [Google Scholar]
- BRYAN A. C., BENTIVOGLIO L. G., BEEREL F., MACLEISH H., ZIDULKA A., BATES D. V. FACTORS AFFECTING REGIONAL DISTRIBUTION OF VENTILATION AND PERFUSION IN THE LUNG. J Appl Physiol. 1964 May;19:395–402. doi: 10.1152/jappl.1964.19.3.395. [DOI] [PubMed] [Google Scholar]
- Collins J. V., Clark T. J., Harris P. W., Townsend J. Intravenous corticosteroids in treatment of acute bronchial asthma. Lancet. 1970 Nov 21;2(7682):1047–1049. doi: 10.1016/s0140-6736(70)90283-7. [DOI] [PubMed] [Google Scholar]
- Gandevia B., Milne J. Occupational asthma and rhinitis due to Western red cedar (Thuja plicata), with special reference to bronchial reactivity. Br J Ind Med. 1970 Jul;27(3):235–244. doi: 10.1136/oem.27.3.235. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MICHELSON A. L., LOWELL F. C. Some effects of change in position on pulmonary function in bronchial asthma. Am J Med. 1958 Feb;24(2):225–228. doi: 10.1016/0002-9343(58)90311-5. [DOI] [PubMed] [Google Scholar]
- McCullagh S. F. Allergenicity of piperazine: a study in environmental aetiology. Br J Ind Med. 1968 Oct;25(4):319–325. doi: 10.1136/oem.25.4.319. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pepys J., Pickering C. A., Loudon H. W. Asthma due to inhaled chemical agents--piperazine dihydrochloride. Clin Allergy. 1972 Jun;2(2):189–196. doi: 10.1111/j.1365-2222.1972.tb01282.x. [DOI] [PubMed] [Google Scholar]