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. 1975 Oct;30(5):543–547. doi: 10.1136/thx.30.5.543

Effect of atropine on sputum production.

M T Lopez-Vidriero, J Costello, T J Clark, I Das, E E Keal, L Reid
PMCID: PMC470323  PMID: 1198394

Abstract

The effect of atropine on sputum production has been studied in patients with asthama, chronic bronchitis, and bronchiectasis in some of whom there was bronchorrhoea. In three patients a reduction in sputum volume was observed after atropine but it would seem that the decrease was mainly due to the inhibitory effect on salivary secretion which facilitates spitting. The one patient treated with long-term oral atropine showed a marked reduction in sputum volume although chemical constituents and viscosity levels remained unchanged, suggesting that in this case atropine had an inhibitory effect on bronchial gland secretion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLANSHARD G. Sputum viscosity and postoperative pulmonary atelectasis. Dis Chest. 1960 Jan;37:75–81. doi: 10.1378/chest.37.1.75. [DOI] [PubMed] [Google Scholar]
  2. CHAMBERLAIN D. A., MUIR D. C., KENNEDY K. P. Atropine methonitrate and isoprenaline in bronchial asthma. Lancet. 1962 Nov 17;2(7264):1019–1021. doi: 10.1016/s0140-6736(62)92704-6. [DOI] [PubMed] [Google Scholar]
  3. EGER E. I., 2nd, KRAFT I. D., K EASLING H. H. A comparison of atropine, or scopolamine, plus pentobarbital, meperidine, or morphine as pediatric preanesthetic medication. Anesthesiology. 1961 Nov-Dec;22:962–969. doi: 10.1097/00000542-196111000-00015. [DOI] [PubMed] [Google Scholar]
  4. FREEMAN A., BACHMAN L. Pediatric anesthesia: an evaluation of preoperative medication. Anesth Analg. 1959 Nov-Dec;38:429–437. [PubMed] [Google Scholar]
  5. HILLIS B. R. The assessment of cough suppressing drugs. Lancet. 1952 Jun 21;1(6721):1230–1235. doi: 10.1016/s0140-6736(52)92060-6. [DOI] [PubMed] [Google Scholar]
  6. HUME K. M., RHYS JONES E. The response to bronchodilators in intrinsic asthma. Q J Med. 1961 Apr;30:189–199. [PubMed] [Google Scholar]
  7. Keal E. E. Biochemistry and rheology of sputum in asthma. Postgrad Med J. 1971 Mar;47(545):171–177. doi: 10.1136/pgmj.47.545.171. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. REID L. Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis. Thorax. 1960 Jun;15:132–141. doi: 10.1136/thx.15.2.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Simonsson B. G., Jacobs F. M., Nadel J. A. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest. 1967 Nov;46(11):1812–1818. doi: 10.1172/JCI105671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Sterling G. M. Mechanism of bronchoconstriction caused by cigarette smoking. Br Med J. 1967 Jul 29;3(5560):275–277. doi: 10.1136/bmj.3.5560.275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Sturgess J., Reid L. Secretory activity of the human bronchial mucous glands in vitro. Exp Mol Pathol. 1972 Jun;16(3):362–381. doi: 10.1016/0014-4800(72)90011-1. [DOI] [PubMed] [Google Scholar]
  12. WARREN L. The thiobarbituric acid assay of sialic acids. J Biol Chem. 1959 Aug;234(8):1971–1975. [PubMed] [Google Scholar]
  13. Yu D. Y., Galant S. P., Gold W. M. Inhibition of antigen-induced bronchoconstriction by atropine in asthmatic patients. J Appl Physiol. 1972 Jun;32(6):823–828. doi: 10.1152/jappl.1972.32.6.823. [DOI] [PubMed] [Google Scholar]

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