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. 1975 Oct;30(5):578–581. doi: 10.1136/thx.30.5.578

Hypothalamo-pituitary-adrenal function in intrinsic non-atopic asthma.

J V Collins, D Bellamy, M G Britton, J Townsend, D J Brown
PMCID: PMC470331  PMID: 1198402

Abstract

Sixteen patients with intrinsic non-atopic asthma with persistent wheezing who had never been treated with corticosteroids showed normal adrenocortical responses to prolonged stimulation with Tetracosactin Depot. In a subgroup of six patients the hypothalamo-pituitary-adrenal (HPA) response to a standard insulin stress test was normal. It is concluded that impaired responsiveness of the HPA axis is unlikely to be a common factor in initiating or maintaining airways obstruction in patients with intrinsic asthma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CARRYER H. M., SHERRICK D. W., GASTINEAU C. F. Occurrence of allergic disease in patients with adrenal cortical hypofunction. J Am Med Assoc. 1960 Mar 26;172:1356–1360. doi: 10.1001/jama.1960.03020130014005. [DOI] [PubMed] [Google Scholar]
  2. Cayton R. M., Howard P. Plasma cortisol and the use of hydrocortisone in the treatment of status asthmaticus. Thorax. 1973 Sep;28(5):567–573. doi: 10.1136/thx.28.5.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Green M., Lim K. H. Bronchial asthma with Addison's disease. Lancet. 1971 Jun 5;1(7710):1159–1162. doi: 10.1016/s0140-6736(71)91664-3. [DOI] [PubMed] [Google Scholar]
  4. HOUSTON J. C., DE NAVASQUEZ S., TROUNCE J. R. A clinical and pathological study of fatal cases of status asthmaticus. Thorax. 1953 Sep;8(3):207–213. doi: 10.1136/thx.8.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. OGILVIE A. G. Asthma: a study in prognosis of 1,000 patients. Thorax. 1962 Sep;17:183–189. doi: 10.1136/thx.17.3.183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. ROBSON A. O., KILBORN J. R. STUDIES OF ADRENOCORTICAL FUNCTION IN CONTINUOUS ASTHMA. Thorax. 1965 Jan;20:93–98. doi: 10.1136/thx.20.1.93. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. STUDZINSKI G. P., HAY D. C., SYMINGTON T. Observations on the weight of the human adrenal gland and the effect of preparations of corticotropin of different purity on the weight and morphology of the human adrenal gland. J Clin Endocrinol Metab. 1963 Mar;23:248–254. doi: 10.1210/jcem-23-3-248. [DOI] [PubMed] [Google Scholar]
  9. Speizer F. E., Doll R., Heaf P., Strang L. B. Investigation into use of drugs preceding death from asthma. Br Med J. 1968 Feb 10;1(5588):339–343. doi: 10.1136/bmj.1.5588.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Weller H. H., Van der Straeten M., Vermeulen A., Orie N. G. Hormonal pattern in bronchial asthma (reversible obstructive lung disease). 1. Role of adrenal steroids. Scand J Respir Dis. 1968;49(3):163–184. [PubMed] [Google Scholar]
  11. Weston M., Kind P. Plasma cortisol and response to corticotrophin in airways obstruction. Br J Dis Chest. 1969 Jan;63(1):48–50. doi: 10.1016/s0007-0971(69)80044-6. [DOI] [PubMed] [Google Scholar]

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