Skip to main content
Thorax logoLink to Thorax
. 1975 Dec;30(6):624–630. doi: 10.1136/thx.30.6.624

Bronchorrhoea.

M Lopez-Vidriero, J Charman, E Keal, L Reid
PMCID: PMC470337  PMID: 176747

Abstract

Bronchorrohea has been defined as a condition in which more than 100 ml of sputum is produced within 24 hours, an amount in excess of that seen in chronic lung diseases. The rheological and chemical characteristics of the sputum are here described. Levels of viscosity, dry weight, N-acetyl neuraminic acid (NANA), fucose, and sulphate fall between those in saliva and mucoid sputum from chronic lung diseases. These levels were always higher in bronchorrhoea sputum than in saliva and therefore may be used in the differential diagnosis of bronchorrhoea and hypersalivation. Bronchorrhoea sputum has the constituents of a bronchial secretion but is low in acid glycoprotein. Certain other features are commonly found - a large amount of froth, increase in viscosity with time, and separation into two phases. Some cases respond to steroids, particularly when the levels of NANA in the sputum are low.

Full text

PDF
624

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANZAI T., BARKER S. A., STACEY M. Sialic acid and its relation to chronic bronchitis. Clin Chim Acta. 1957 Dec;2(6):491–496. doi: 10.1016/0009-8981(57)90051-7. [DOI] [PubMed] [Google Scholar]
  2. ASHCROFT T. DAILY VARIATIONS IN SPUTUM VOLUME IN CHRONIC BRONCHITIS. Br Med J. 1965 Jan 30;1(5430):288–290. doi: 10.1136/bmj.1.5430.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. ATASSI M. Z., BARKER S. A., HOUGHTON L. E., STACEY M. Neuraminic acid and its relation to chronic bronchitis. II. Clin Chim Acta. 1959 Sep;4:741–747. doi: 10.1016/0009-8981(59)90019-1. [DOI] [PubMed] [Google Scholar]
  4. Calin A. Bronchorrhoea. Br Med J. 1972 Nov 4;4(5835):274–275. doi: 10.1136/bmj.4.5835.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Charman J., Reid L. Sputum viscosity in chronic bronchitis, bronchiectasis, asthma and cystic fibrosis. Biorheology. 1972 Sep;9(3):185–199. doi: 10.3233/bir-1972-9310. [DOI] [PubMed] [Google Scholar]
  6. GERNEZ-RIEUX C., BISERTE G., HAVEZ R., VOISIN C., ROUSSEL P., DEGAND P. ETUDE DE L'ACTIVIT'E "IN VITRO" DE DIFF'ERENTS AGENTS R'EDUISANT LA VISCOSIT'E DE L'EXPECTORATION. Acta Tuberc Pneumol Belg. 1964 May-Jun;55:138–164. [PubMed] [Google Scholar]
  7. KENNAMER R. Pulmonary adenomatosis; report of a case. J Am Med Assoc. 1951 Mar 17;145(11):815–818. doi: 10.1001/jama.1951.72920290005008b. [DOI] [PubMed] [Google Scholar]
  8. LEACH S. A. RELEASE AND BREAKDOWN OF SIALIC ACID FROM HUMAN SALIVARY MUCIN AND ITS ROLE IN THE FORMATION OF DENTAL PLAQUE. Nature. 1963 Aug 3;199:486–487. doi: 10.1038/199486a0. [DOI] [PubMed] [Google Scholar]
  9. MILLER D. L., TINKER C. M., FLETCHER C. M. MEASUREMENT OF SPUTUM VOLUME IN FACTORY AND OFFICE WORKERS. Br Med J. 1965 Jan 30;1(5430):291–293. doi: 10.1136/bmj.1.5430.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Palmer K. N., Ballantyne D., Diament M. L., Hamilton W. F. The rheology of bronchitic sputum. Br J Dis Chest. 1970 Oct;64(4):185–191. doi: 10.1016/s0007-0971(70)80014-6. [DOI] [PubMed] [Google Scholar]
  11. Puchelle E., Zahm J. M., Havez R. Données biochimiques er rhéologiques dans l'expectoration. 3. Relation des protéines et mucines bronchiques avec les propriétés rhéologiques. Bull Physiopathol Respir (Nancy) 1973 Mar-Apr;9(2):237–257. [PubMed] [Google Scholar]
  12. RUBINSTEIN P., PILHEU J. A. Consideraciones sobre la broncorrea seromucosa. Rev Asoc Med Argent. 1954 Sep 15;68(781-782):471–473. [PubMed] [Google Scholar]
  13. SCHOOLS G. S., RAY E. S. Bronchiolar carcinoma. A case report of bronchoscopic observation of servere bronchorrhea. Dis Chest. 1961 Jun;39:643–645. doi: 10.1378/chest.39.6.643. [DOI] [PubMed] [Google Scholar]
  14. STOREY C. F., KNUDTSON K. P., LAWRENCE B. J. Bronchiolar (alveolar cell) carcinoma of the lung. J Thorac Surg. 1953 Oct;26(4):331–406. [PubMed] [Google Scholar]
  15. Sturgess J. M., Palfrey A. J., Reid L. The viscosity of bronchial secretion. Clin Sci. 1970 Jan;38(1):145–156. doi: 10.1042/cs0380145. [DOI] [PubMed] [Google Scholar]
  16. TURIAF J., MARLAND P., SORS C. Carcinose alveolaire du poumon radiologiquement muette. J Fr Med Chir Thorac. 1957;11(2):115–125. [PubMed] [Google Scholar]
  17. WARREN L. The thiobarbituric acid assay of sialic acids. J Biol Chem. 1959 Aug;234(8):1971–1975. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES