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. 1976 Feb;31(1):15–24. doi: 10.1136/thx.31.1.15

Pleuropneumonectomy in the management of diffuse malignant mesothelioma of the pleura. Experience with 29 patients.

E G Butchart, T Ashcroft, W C Barnsley, M P Holden
PMCID: PMC470356  PMID: 1257933

Abstract

An analysis is made of the results of pleuropneumonectomy for diffuse malignant pleural mesothelioma in 29 patients and a comparison is made with the results of non-surgical treatment in a further 17 patients. A system of tumour staging is proposed, and the results are correlated with tumour stage and with histological type. Pleuropneumonectomy does not appear materially to affect the course of the disease in cases of mixed epithelial and mesenchymal histological type. However, stage I cases of pure epithelial histological type appear to carry a better prognosis, especially those whose histological structure consists entirely of abundant oedematous mucoid stroma with loosely arranged tumour cells. It is suggested therefore that only epithelial cases should be subjected to pleuropneumonectomy. Means of reducing operative mortality are discussed and alternative methods of treatment described.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson C. B., Philpott G. W., Ferguson T. B. The treatment of malignant pleural effusions. Cancer. 1974 Apr;33(4):916–922. doi: 10.1002/1097-0142(197404)33:4<916::aid-cncr2820330405>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  2. Ashcroft T. Epidemiological and quantitative relationships between mesothelioma and asbestos on Tyneside. J Clin Pathol. 1973 Nov;26(11):832–840. doi: 10.1136/jcp.26.11.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bartoszewicz T. Złośliwe miedzybłoniaki opłucnej. Pol Przegl Chir. 1971 Nov;43(11):1733–1740. [PubMed] [Google Scholar]
  4. EHRENHAFT J. L., SENSENIG D. M., LAWRENCE M. S. Mesotheliomas of the pleura. J Thorac Cardiovasc Surg. 1960 Sep;40:393–409. [PubMed] [Google Scholar]
  5. Eschwege F., Schlienger M. La radiothérapie des mésothéliomes pleuraux malins. A propos de 14 cas irradiés à doses élevées. J Radiol Electrol Med Nucl. 1973 Mar;54(3):255–259. [PubMed] [Google Scholar]
  6. HARRIS M. S., HYMAN M. M., NEVIUS D. B. A resectable form of multiple mesothelioma. Dis Chest. 1959 Feb;35(2):127–133. doi: 10.1378/chest.35.2.127. [DOI] [PubMed] [Google Scholar]
  7. HOURIHANE D. O. THE PATHOLOGY OF MESOTHELIOMATA AND AN ANALYSIS OF THEIR ASSOCIATION WITH ASBESTOS EXPOSURE. Thorax. 1964 May;19:268–278. doi: 10.1136/thx.19.3.268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Herrmann K., Herrmann R. M. Probleme der Diagnostik und Behandlung von Pleuramesotheliomen. Arch Geschwulstforsch. 1972;40(4):355–361. [PubMed] [Google Scholar]
  9. Hertzog P., Toty L. Pronostic du traitement chirurgical des tumeurs malignes primitives de la plèvre. Poumon Coeur. 1968;24(5):529–535. [PubMed] [Google Scholar]
  10. Lanitis G., Waridel D. Les tumeurs primitives de la plèvre. Rev Med Suisse Romande. 1973 Feb;93(2):115–131. [PubMed] [Google Scholar]
  11. Leininger B. J., Barker W. L., Langston H. T. A simplified method for management of malignant pleural effusion. J Thorac Cardiovasc Surg. 1969 Nov;58(5):758–763. [PubMed] [Google Scholar]
  12. McCAUGHEY W. T. Primary tumours of the pleura. J Pathol Bacteriol. 1958 Oct;76(2):517–529. doi: 10.1002/path.1700760222. [DOI] [PubMed] [Google Scholar]
  13. Merlier M., Le Brigand H., Wapler C. Chirurgie des tumeurs pleurales primitives. Poumon Coeur. 1968;24(5):521–527. [PubMed] [Google Scholar]
  14. Porter J. M., Cheek J. M. Pleural mesothelioma review of tumor histogenesis and report of 12 cases. J Thorac Cardiovasc Surg. 1968 Jun;55(6):882–890. [PubMed] [Google Scholar]
  15. Prorok J., Nealon T. F., Jr Pleural symphysis by talc poudrage in the treatment of malignant pleural effusion. Bull Soc Int Chir. 1968 Nov-Dec;27(6):630–636. [PubMed] [Google Scholar]
  16. SALZER G. [Diffuse pleural tumors as a surgical problem]. Thoraxchirurgie. 1959 Dec;7:377–382. doi: 10.1055/s-0028-1101394. [DOI] [PubMed] [Google Scholar]
  17. STEVENS G. M., MCCORT J. J. ABDOMINAL PNEUMOPERITONEOGRAPHY. Radiology. 1964 Sep;83:480–485. doi: 10.1148/83.3.480. [DOI] [PubMed] [Google Scholar]
  18. Scarbonchi J., Razzouk H. Traitement palliatif des épanchements pleuraux néoplasiques. Talcage des plèvres sous pleuroscopie avec un mélange de talc et de Virgimycine. Mars Med. 1967;104(11):939–947. [PubMed] [Google Scholar]
  19. Schlienger M., Eschwège F., Blaché R., Depierre R. Mésothéliomes pleuraux malins. Etude de 39 cas dont 25 autopsies. Bull Cancer. 1969 Jul-Sep;56(3):265–308. [PubMed] [Google Scholar]
  20. Seliverstov V. E. Radikal'naia operatsiia pri pervichnoi diffuznoi mezoteliome plevry. Grudn Khir. 1970 Nov-Dec;12(6):104–106. [PubMed] [Google Scholar]
  21. TRIMBLE H. G., LEFTWICH W. B. The diagnostic use of artificial pneumoperitoneum. Dis Chest. 1955 Sep;28(3):282–289. doi: 10.1378/chest.28.3.282. [DOI] [PubMed] [Google Scholar]
  22. Whitwell F., Rawcliffe R. M. Diffuse malignant pleural mesothelioma and asbestos exposure. Thorax. 1971 Jan;26(1):6–22. doi: 10.1136/thx.26.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]

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