Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1976 Feb;31(1):94–100. doi: 10.1136/thx.31.1.94

Hypoxia and lung mast cells: influence of disodium cromoglycate.

I P Mungall
PMCID: PMC470368  PMID: 130695

Abstract

Rats kept in 10% O2 for three or more weeks developed mast cell hyperplasia in the lungs, especially round the alveoli and the small peripheral blood vessels, which became thickened during chronic hypoxia. There was a significant correlation between the degree of right ventricular hypertrophy (RVH) and the numbers of alveolar and small vessel mast cells. However, mast cell hyperplasia developed more slowly than RVH. Daily treatment with disodium cromoglycate failed to prevent RVH in hypoxic conditions but was associated with retardation of growth in both hypoxic and control rats. Neither acute nor chronic hypoxia increased the degree of degranulation in the lung mast cells.

Full text

PDF
94

Images in this article

98Image
on p.98

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abraham A. S., Cumming A. G., Horsfield R., Prowse K. Regional hypoxia and distribution of pulmonary blood flow. Scand J Respir Dis. 1970;51(1):33–36. [PubMed] [Google Scholar]
  2. Assem E. S., Richter A. W. Comparison of in vivo and in vitro inhibition of the anaphylactic mechanism by beta-adrenergic stimulants and disodium cromoglycate. Immunology. 1971 Nov;21(5):729–739. [PMC free article] [PubMed] [Google Scholar]
  3. Aviado D. M., Samanék M., Folle L. E. Cardiopulmonary effects of tobacco and related substances. I. The release of histamine during inhalation of cigarette smoke and anoxemia in the heart-lung and intact dog preparation. Arch Environ Health. 1966 Jun;12(6):705–711. doi: 10.1080/00039896.1966.10664468. [DOI] [PubMed] [Google Scholar]
  4. Barer G. R., Howard P., McCurrie J. R., Shaw J. W. Changes in the pulmonary circulation after bronchial occlusion in anesthetized dogs and cats. Circ Res. 1969 Dec;25(6):747–764. doi: 10.1161/01.res.25.6.747. [DOI] [PubMed] [Google Scholar]
  5. Barer G. R., McCurrie J. R. Pulmonary vasomotor responses in the cat; the effects and interrelationships of drugs, hypoxia and hypercapnia. Q J Exp Physiol Cogn Med Sci. 1969 Apr;54(2):156–172. doi: 10.1113/expphysiol.1969.sp002014. [DOI] [PubMed] [Google Scholar]
  6. Brashear R. E., Martin R. R., Ross J. C. In vivo histamine levels with hypoxia and compound 48-80. Am J Med Sci. 1970 Jul;260(1):21–28. [PubMed] [Google Scholar]
  7. Clarke P. S. Effect of disodium cromoglycate on exacerbations of asthma produced by hyperventilation. Br Med J. 1971 Feb 6;1(5744):317–319. doi: 10.1136/bmj.1.5744.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cox J. S. Disodium cromoglycate (FPL 670) ('Intal'): a specific inhibitor of reaginic antibody-antigen mechanisms. Nature. 1967 Dec 30;216(5122):1328–1329. doi: 10.1038/2161328a0. [DOI] [PubMed] [Google Scholar]
  9. Cryer A., Bartley W. The design and use of a hypoxic chamber for small animals. Lab Pract. 1974 Dec;23(12):713–715. [PubMed] [Google Scholar]
  10. Davies S. E. Effect of disodium cromoglycate on exercise-induced asthma. Br Med J. 1968 Sep 7;3(5618):593–594. doi: 10.1136/bmj.3.5618.593. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Dawson C. A., Delano F. A., Hamilton L. H., Stekiel W. J. Histamine releasers and hypoxic vasoconstriction in isolated cat lungs. J Appl Physiol. 1974 Nov;37(5):670–674. doi: 10.1152/jappl.1974.37.5.670. [DOI] [PubMed] [Google Scholar]
  12. FAWCETT D. W. Cytological and pharmacological observations on the release of histamine by mast cells. J Exp Med. 1954 Aug 1;100(2):217–224. doi: 10.1084/jem.100.2.217. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Haas F., Bergofsky E. H. Role of the mast cell in the pulmonary pressor response to hypoxia. J Clin Invest. 1972 Dec;51(12):3154–3162. doi: 10.1172/JCI107142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hasleton P. S., Heath D., Brewer D. B. Hypertensive pulmonary vascular disease in states of chronic hypoxia. J Pathol Bacteriol. 1968 Apr;95(2):431–440. doi: 10.1002/path.1700950213. [DOI] [PubMed] [Google Scholar]
  15. Hauge A. Role of histamine in hypoxic pulmonary hypertension in the rat. I. Blockade or potentiation of endogenous amines, kinins, and ATP. Circ Res. 1968 Mar;22(3):371–383. doi: 10.1161/01.res.22.3.371. [DOI] [PubMed] [Google Scholar]
  16. Hauge A., Staub N. C. Prevention of hypoxic vasoconstriction in cat lung by histamine-releasing agent 48/80. J Appl Physiol. 1969 Jun;26(6):693–699. doi: 10.1152/jappl.1969.26.6.693. [DOI] [PubMed] [Google Scholar]
  17. Heath D., Trueman T., Sukonthamarn P. Pulmonary mast cells in mitral stenosis. Cardiovasc Res. 1969 Oct;3(4):467–471. doi: 10.1093/cvr/3.4.467. [DOI] [PubMed] [Google Scholar]
  18. Hicken P., Heath D., Brewer D. B., Whitaker W. The small pulmonary arteries in emphysema. J Pathol Bacteriol. 1965 Jul;90(1):107–114. doi: 10.1002/path.1700900111. [DOI] [PubMed] [Google Scholar]
  19. Hunter C., Barer G. R., Shaw J. W., Clegg E. J. Growth of the heart and lungs in hypoxic rodents: a model of human hypoxic disease. Clin Sci Mol Med. 1974 Mar;46(3):375–391. doi: 10.1042/cs0460375. [DOI] [PubMed] [Google Scholar]
  20. Kay J. M., Gillund T. D., Heath D. Mast cells in the lungs of rats fed on Crotalaria spectabilis seeds. Am J Pathol. 1967 Dec;51(6):1031–1044. [PMC free article] [PubMed] [Google Scholar]
  21. Kay J. M., Waymire J. C., Grover R. F. Lung mast cell hyperplasia and pulmonary histamine-forming capacity in hypoxic rats. Am J Physiol. 1974 Jan;226(1):178–184. doi: 10.1152/ajplegacy.1974.226.1.178. [DOI] [PubMed] [Google Scholar]
  22. Kerr J. W., Govindaraj M., Patel K. R. Effect of alpha-receptor blocking drugs and disodium cromoglyate on histamine hypersensitivity in bronchial asthma. Br Med J. 1970 Apr 18;2(5702):139–141. doi: 10.1136/bmj.2.5702.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Marshall R. Protective effect of disodium cromoglycate on rat peritoneal mast cells. Thorax. 1972 Jan;27(1):38–43. doi: 10.1136/thx.27.1.38. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. McGrath J. J., Procházka J., Pelouch V., Ostádal B. Physiological responses of rats to intermittent high-altitude stress: effects of age. J Appl Physiol. 1973 Mar;34(3):289–293. doi: 10.1152/jappl.1973.34.3.289. [DOI] [PubMed] [Google Scholar]
  25. Orr T. S., Cox J. S. Disodium cromoglycate, an inhibitor of mas cell degranulation and histamine release induced by phospholipase A. Nature. 1969 Jul 12;223(5202):197–198. doi: 10.1038/223197b0. [DOI] [PubMed] [Google Scholar]
  26. Pepys J., Hargreave F. E., Chan M., McCarthy D. S. Inhibitory effects of disodium cromoglycate on allergen-inhalation tests. Lancet. 1968 Jul 20;2(7560):134–137. doi: 10.1016/s0140-6736(68)90419-4. [DOI] [PubMed] [Google Scholar]
  27. RILEY J. F., WEST G. B. The presence of histamine in tissue mast cells. J Physiol. 1953 Jun 29;120(4):528–537. doi: 10.1113/jphysiol.1953.sp004915. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. RILEY J. F., WEST G. B. Tissue mast cells: studies with a histamine-liberator of low toxicity (compound 48/80). J Pathol Bacteriol. 1955 Jan-Apr;69(1-2):269–282. doi: 10.1002/path.1700690135. [DOI] [PubMed] [Google Scholar]
  29. TAKEOKA O., ANGEVINE D. M., LALICH J. J. Stimulation of mast cells in rats fed various chemicals. Am J Pathol. 1962 May;40:545–554. [PMC free article] [PubMed] [Google Scholar]
  30. Widimsky J., Urbanova D., Ressl J., Ostadal B., Pelouch V., Prochazka J. Myocardial function in chronic pulmonary diseases. The effect of intermittent altitude hypoxia on the myocardium in rats. Preliminary communication. Bull Physiopathol Respir (Nancy) 1972 Nov-Dec;8(6):1400–1405. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES