Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1976 Apr;31(2):172–177. doi: 10.1136/thx.31.2.172

Aortocoronary graft flow and reactive hyperaemia in relation to postoperative myocardial infarction.

S Skotnicki, J Vonk, T Sleegers, S Dercksen, G Linssen, L Lacquet, P Kuijpers
PMCID: PMC470380  PMID: 781900

Abstract

Blood flow through aortocoronary venous grafts and its response to a brief period of arterial occlusion--reactive hyperaemia--were studied in relation to the development of postoperative myocardial infarction. In 40 patients with intractable angina due to obstructive coronary artery disease, 72 aortocoronary venous grafts were constructed. In 18% of the grafts there was no response to the flow to temporary occlusion, due to absence of reactive hyperaemia. In the remaining grafts the flow increased from 17% to 26%. In 17-5% of the patients postoperative myocardial infarction was diagnosed. No relation could be established between this control flow through aortocoronary grafts and postoperative myocardial infarction. A significant difference was found in the magnitude of the reactive hyperaemia following occlusion of the graft between patients who developed myocardial infarction (13-0%) and those who did not (26-8%). Some of our observations suggest that the myocardium is in a state of reactive hyperaemia after coronary surgery. With certain technical precautions the flow changes caused by reactive hyperaemia can be used as an indicator of the result to be expected from bypass surgery.

Full text

PDF
172

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bittar N., Kroncke G. M., Dacumos G. C., Jr, Rowe G. G., Young W. P., Chopra P. S., Folts J. D., Kahn D. R. Vein graft flow and reactive hyperemia in the human heart. J Thorac Cardiovasc Surg. 1972 Dec;64(6):855–860. [PubMed] [Google Scholar]
  2. Bolooki H., Sommer L., Faraldo A., Ghahramani A., Slavin D., Kaiser G. A. The significance of serum enzyme studies in patients undergoing direct coronary artery surgery. J Thorac Cardiovasc Surg. 1973 Jun;65(6):863–868. [PubMed] [Google Scholar]
  3. Brewer D. L., Bilbro R. H., Bartel A. G. Myocardial infarction as a complication of coronary bypass surgery. Circulation. 1973 Jan;47(1):58–64. doi: 10.1161/01.cir.47.1.58. [DOI] [PubMed] [Google Scholar]
  4. COFFMAN J. D., GREGG D. E. Reactive hyperemia characteristics of the myocardium. Am J Physiol. 1960 Dec;199:1143–1149. doi: 10.1152/ajplegacy.1960.199.6.1143. [DOI] [PubMed] [Google Scholar]
  5. Cooley D. A., Dawson J. T., Hallman G. L., Sandiford F. M., Wukasch D. C., Garcia E., Hall R. J. Aortocoronary saphenous vein bypass. Results in 1,492 patients, with particular reference to patients with complicating features. Ann Thorac Surg. 1973 Oct;16(4):380–390. doi: 10.1016/s0003-4975(10)65009-6. [DOI] [PubMed] [Google Scholar]
  6. Edwards W. S. Blood flow measurements during coronary artery bypass operations. Ann Thorac Surg. 1971 Dec;12(6):663–664. doi: 10.1016/s0003-4975(10)64803-5. [DOI] [PubMed] [Google Scholar]
  7. Favaloro R. G., Effler D. B., Groves L. K., Sheldon W. C., Sones F. M., Jr Direct myocardial revascularization by saphenous vein graft. Present operative technique and indications. Ann Thorac Surg. 1970 Aug;10(2):97–111. doi: 10.1016/s0003-4975(10)65574-9. [DOI] [PubMed] [Google Scholar]
  8. Furuse A., Klopp E. H., Brawley R. K., Gott V. L. Hemodynamics of aorta-to-coronary artery bypass. Experimental and analytical studies. Ann Thorac Surg. 1972 Sep;14(3):282–293. doi: 10.1016/s0003-4975(10)65230-7. [DOI] [PubMed] [Google Scholar]
  9. Grondin C. M., Castonguay Y. R., Lespérance J., Bourassa M. G., Campeau L., Grondin P. Attrition rate of aorta-to-coronary artery saphenous vein grafts after one year. A study in a consecutive series of 96 patients. Ann Thorac Surg. 1972 Sep;14(3):223–231. doi: 10.1016/s0003-4975(10)65225-3. [DOI] [PubMed] [Google Scholar]
  10. Grondin C. M., Lespérance J., Bourassa M. G., Pasternac A., Campneau L., Grondin P. Serial angiograpic evaluation in 60 consecutive patients with aorto-coronary artery vein grafts 2 weeks, 1 year, and 3 years after operation. J Thorac Cardiovasc Surg. 1974 Jan;67(1):1–6. [PubMed] [Google Scholar]
  11. Grondin C. M., Meere C., Castonguay Y. R., Lepage G., Grondin P. Blood flow through aorta-to-coronary artery bypass grafts and early postoperative patency. A study of 100 patients. Ann Thorac Surg. 1971 Dec;12(6):574–581. doi: 10.1016/s0003-4975(10)64792-3. [DOI] [PubMed] [Google Scholar]
  12. Johnson W. D., Lepley D., Jr An aggressive surgical approach to coronary disease. J Thorac Cardiovasc Surg. 1970 Jan;59(1):128–138. [PubMed] [Google Scholar]
  13. Khouri E. M., Gregg D. E., Lowensohn H. S. Flow in the major branches of the left coronary artery during experimental coronary insufficiency in the unanesthetized dog. Circ Res. 1968 Jul;23(1):99–109. doi: 10.1161/01.res.23.1.99. [DOI] [PubMed] [Google Scholar]
  14. OLSSON R. A., GREGG D. E. MYOCARDIAL REACTIVE HYPEREMIA IN THE UNANESTHETIZED DOG. Am J Physiol. 1965 Feb;208:224–230. doi: 10.1152/ajplegacy.1965.208.2.224. [DOI] [PubMed] [Google Scholar]
  15. Reneman R. S., Spencer M. P. The use of diastolic reactive hyperemia to evaluate the coronary vascular system. Ann Thorac Surg. 1972 May;13(5):477–487. doi: 10.1016/s0003-4975(10)65161-2. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES