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. 1974 Jan;29(1):90–94. doi: 10.1136/thx.29.1.90

Development of the acinus in the human lung

Alison Hislop 1, Lynne Reid 1
PMCID: PMC470408  PMID: 4825556

Abstract

Hislop, Alison, and Reid, Lynne (1974).Thorax, 29, 90-94. Development of the acinus in the human lung. Development and remodelling of the acinus (those structures distal to the terminal bronchiolus) occurs during fetal life and childhood. Multiplication of the acinar air spaces and the structural changes they undergo have been described and represented schematically by summarizing previous studies, particularly those of the last two decades.

Most acinar airways are present before birth. Future respiratory bronchioli are represented by the 19th intrauterine week; alveolar ducts are present as saccules by the 28th week. Alveolar sacs and alveoli, as properly described, do not appear until after birth: alveoli increase in number, particularly in the first seven or so years of life, and in size with thoracic growth.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Angus G. E., Thurlbeck W. M. Number of alveoli in the human lung. J Appl Physiol. 1972 Apr;32(4):483–485. doi: 10.1152/jappl.1972.32.4.483. [DOI] [PubMed] [Google Scholar]
  2. BOYDEN E. A. THE TERMINAL AIR SACS AND THEIR BLOOD SUPPLY IN A 37-DAY INFANT LUNG. Am J Anat. 1965 Mar;116:413–428. doi: 10.1002/aja.1001160207. [DOI] [PubMed] [Google Scholar]
  3. BUCHER U., REID L. Development of the intrasegmental bronchial tree: the pattern of branching and development of cartilage at various stages of intra-uterine life. Thorax. 1961 Sep;16:207–218. doi: 10.1136/thx.16.3.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Boyden E. A., Tompsett D. H. The changing patterns in the developing lungs of infants. Acta Anat (Basel) 1965;61(2):164–192. doi: 10.1159/000142692. [DOI] [PubMed] [Google Scholar]
  5. CAMPICHE M. A., GAUTIER A., HERNANDEZ E. I., REYMOND A. AN ELECTRON MICROSCOPE STUDY OF THE FETAL DEVELOPMENT OF HUMAN LUNG. Pediatrics. 1963 Dec;32:976–994. [PubMed] [Google Scholar]
  6. Davies G., Reid L. Growth of the alveoli and pulmonary arteries in childhood. Thorax. 1970 Nov;25(6):669–681. doi: 10.1136/thx.25.6.669. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. ELLIOTT F. M., REID L. SOME NEW FACTS ABOUT THE PULMONARY ARTERY AND ITS BRANCHING PATTERN. Clin Radiol. 1965 Jul;16:193–198. doi: 10.1016/s0009-9260(65)80042-3. [DOI] [PubMed] [Google Scholar]
  8. Hislop A., Reid L. Intra-pulmonary arterial development during fetal life-branching pattern and structure. J Anat. 1972 Oct;113(Pt 1):35–48. [PMC free article] [PubMed] [Google Scholar]
  9. LAMBERT M. W. Accessory bronchiolealveolar communications. J Pathol Bacteriol. 1955 Oct;70(2):311–314. doi: 10.1002/path.1700700206. [DOI] [PubMed] [Google Scholar]
  10. Meyrick B., Reid L. The alveolar wall. Br J Dis Chest. 1970 Jul;64(3):121–140. doi: 10.1016/s0007-0971(70)80001-8. [DOI] [PubMed] [Google Scholar]
  11. REID L., RUBINO M. The connective tissue septa in the foetal human lung. Thorax. 1959 Mar;14(1):3–13. doi: 10.1136/thx.14.1.3. [DOI] [PMC free article] [PubMed] [Google Scholar]

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