Skip to main content
Thorax logoLink to Thorax
. 1976 Oct;31(5):552–557. doi: 10.1136/thx.31.5.552

Diagnostic value of serum angiotensin converting enzyme activity in lung diseases.

K Ashutosh, J F Keighley
PMCID: PMC470474  PMID: 186911

Abstract

Serum angiotensin converting enzyme (ACE) activity was measured in 10 patients with early active sarcoidosis, nine patients with inactive or resolving sarcoidosis, 10 patients with malignant pulmonary neoplasms, eight patients with miscellaneous lung diseases, and 18 control subjects with no known pulmonary disease. The serum ACE activity, expressed in units/ml, in control subjects (5-88 +/- 1-84), was no different from the values obtained in patients with inactive or resolving sarcoidosis (6-85 +/- 2-48) or miscellaneous lung diseases (4-61 +/- 3-20). However, the ACE activity was found to be markedly raised in patients with early active sarcoidosis (13-49 +/- 2-52), and there was no overlap with control values. The patients with pulmonary neoplasms had significantly lower values of serum ACE activity than the control subjects (2-80 +/- 3-30).

Full text

PDF
552

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ghose T., Landrigan P., Asif A. Localization of immunoglobulin and complement in pulmonary sarcoid granulomas. Chest. 1974 Sep;66(3):264–268. doi: 10.1378/chest.66.3.264. [DOI] [PubMed] [Google Scholar]
  2. Grandino A., Paiva A. C. Isolation of angiotensin-converting enzyme without kininase activity from hog and guinea pig plasma. Biochim Biophys Acta. 1974 Sep 11;364(1):113–119. doi: 10.1016/0005-2744(74)90138-7. [DOI] [PubMed] [Google Scholar]
  3. Holland J., Milic-Emili J., Macklem P. T., Bates D. V. Regional distribution of pulmonary ventilation and perfusion in elderly subjects. J Clin Invest. 1968 Jan;47(1):81–92. doi: 10.1172/JCI105717. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. James D. G., Neville E., Walker A. Immunology of sarcoidosis. Am J Med. 1975 Sep;59(3):388–394. doi: 10.1016/0002-9343(75)90397-6. [DOI] [PubMed] [Google Scholar]
  5. Lieberman J. Elevation of serum angiotensin-converting-enzyme (ACE) level in sarcoidosis. Am J Med. 1975 Sep;59(3):365–372. doi: 10.1016/0002-9343(75)90395-2. [DOI] [PubMed] [Google Scholar]
  6. Molteni A., Zakheim R. M., Mullis K. B., Mattioli L. The effect of chronic alveolar hypoxia on lung and serum angiotensin I converting enzyme activity. Proc Soc Exp Biol Med. 1974 Oct;147(1):263–265. doi: 10.3181/00379727-147-38323. [DOI] [PubMed] [Google Scholar]
  7. Ng K. K., Vane J. R. Conversion of angiotensin I to angiotensin II. Nature. 1967 Nov 25;216(5117):762–766. doi: 10.1038/216762a0. [DOI] [PubMed] [Google Scholar]
  8. Pascual R. S., Gee J. B., Finch S. C. Usefulness of serum lysozyme measurement in diagnosis and evaluation of sarcoidosis. N Engl J Med. 1973 Nov 15;289(20):1074–1076. doi: 10.1056/NEJM197311152892007. [DOI] [PubMed] [Google Scholar]
  9. Ryan J. W., Smith U., Niemeyer R. S. Angiotensin I: metabolism by plasma membrane of lung. Science. 1972 Apr 7;176(4030):64–66. doi: 10.1126/science.176.4030.64. [DOI] [PubMed] [Google Scholar]
  10. SKEGGS L. T., Jr, KAHN J. R., SHUMWAY N. P. The preparation and function of the hypertensin-converting enzyme. J Exp Med. 1956 Mar 1;103(3):295–299. doi: 10.1084/jem.103.3.295. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. TERMAN J. W., NEWTON J. L. CHANGES IN ALVEOLAR AND ARTERIAL GAS TENSIONS AS RELATED TO ALTITUDE AND AGE. J Appl Physiol. 1964 Jan;19:21–24. doi: 10.1152/jappl.1964.19.1.21. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES