Abstract
Forty-six cases of primary bronchogenic carcinoma occurring in patients with other unilateral pleuropulmonary diseases were studied. In 37 cases (80-4%) carcinoma developed in the previously healthy lung. All but one squamous-cell carcinoma and all of five undifferentiated small-cell carcinomas developed in the previously healthy lung while 7 of 15 adenocarcinomas were in the lung with impaired ventilation. It is suggested that the bronchial epithelium of the healthy lung is more exposed to exogenous carcinogens than that of the diseased, underventilated lung, resulting in a higher risk of development of squamous-cell and undifferentiated small-cell carcinoma.
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Selected References
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- Shields T. W., Robinette C. D. Long term survivors after resection of bronchial carcinoma. Surg Gynecol Obstet. 1973 May;136(5):759–762. [PubMed] [Google Scholar]
- Smith R. A. Long-term clinical follow-up after operation for lung carcinoma. Thorax. 1970 Jan;25(1):62–76. doi: 10.1136/thx.25.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATSON W. L. TEN-YEAR SURVIVAL IN LUNG CANCER. A STUDY OF 56 CASES. Cancer. 1965 Feb;18:133–135. doi: 10.1002/1097-0142(196502)18:2<133::aid-cncr2820180202>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
- WEISSMAN H. Bronchogenic carcinoma and pulmonary tuberculosis; problems in diagnosis with special reference to antituberculous chemotherapy. Am Rev Tuberc. 1956 Jun;73(6):853–867. doi: 10.1164/artpd.1956.73.6.853. [DOI] [PubMed] [Google Scholar]