Abstract
In an endeavour to elucidate the anatomical basis for the increased resistance to airflow which characterises the most peripheral conducting air passages in pulmonary emphysema, lumina of nonrespiratory bronchioles of lungs with mainly centrilobular disease were assessed for two- and three-dimensional features by: (1) determination of percentage conformity of the lumina of individual bronchioles in histological sections to hypothetical planes through cylinders (ie, ellipses with the same areas and circumferences), and (2) comparison of luminal areas at regular intervals along bronchiolar longitudinal axes. The lumina of most nonrespiratory bronchioles from normal lungs conformed closely to their respective ellipses, thus corroborating previous observations that they are normally cylindroid. In contrast, there was a substantial excess of plane section deformities in the lumina of nonrespiratory bronchioles from the emphysematous specimens. The incidence of stenotic bronchioles (by both diameter and area determinations) was also greatly increased in emphysema. Since there was a strong positive association between such stenotic lesions and bronchiolar deformity, the latter was concluded to be a major factor in bronchiolar restriction. Furthermore, these characteristics seemed to have three-dimensional expression, for the lumina of stenotic bronchioles in emphysema were irregular in a longitudinal fashion.
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- ANDERSON A. E., Jr, FORAKER A. G. Relative dimensions of bronchioles and parenchymal spaces in lungs from normal subjects and emphysematous patients. Am J Med. 1962 Feb;32:218–226. doi: 10.1016/0002-9343(62)90291-7. [DOI] [PubMed] [Google Scholar]
- ANDERSON W. F., ANDERSON A. E., Jr, HERNANDEZ J. A., FORAKER A. G. TOPOGRAPHY OF AGING AND EMPHYSEMATOUS LUNGS. Am Rev Respir Dis. 1964 Sep;90:411–423. doi: 10.1164/arrd.1964.90.3.411. [DOI] [PubMed] [Google Scholar]
- Anderson A. E., Jr, Foraker A. G. The nonrespiratory bronchioles in pulmonary emphysema. Pathol Annu. 1974;9(0):231–261. [PubMed] [Google Scholar]
- DAYMAN H. Mechanics of airflow in health and in emphysema. J Clin Invest. 1951 Nov;30(11):1175–1190. doi: 10.1172/JCI102537. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hogg J. C., Macklem P. T., Thurlbeck W. M. Site and nature of airway obstruction in chronic obstructive lung disease. N Engl J Med. 1968 Jun 20;278(25):1355–1360. doi: 10.1056/NEJM196806202782501. [DOI] [PubMed] [Google Scholar]
- Linhartová A., Anderson A. E., Foraker A. G. Nonrespiratory bronchiolar deformities. Graphic assessment in normal and emphysematous lungs. Arch Pathol. 1973 Jan;95(1):45–47. [PubMed] [Google Scholar]
- Linhartová A., Anderson A. E., Jr, Foraker A. G. Topology of nonrespiratory bronchioles of normal and emphysematous lungs. Hum Pathol. 1974 Nov;5(6):729–735. doi: 10.1016/s0046-8177(74)80042-0. [DOI] [PubMed] [Google Scholar]
- Linhartová A., Anderson A. e., Jr, Foraker A. G. Radial traction and bronchiolar obstruction in pulmonary emphysema. Observed and theoretical aspects. Arch Pathol. 1971 Nov;92(5):384–391. [PubMed] [Google Scholar]
- Matsuba K., Thurlbeck W. M. The number and dimensions of small airways in emphysematous lungs. Am J Pathol. 1972 May;67(2):265–275. [PMC free article] [PubMed] [Google Scholar]
- Matsuba K., Thurlbeck W. M. The number and dimensions of small airways in nonemphysematous lungs. Am Rev Respir Dis. 1971 Oct;104(4):516–524. doi: 10.1164/arrd.1971.104.4.516. [DOI] [PubMed] [Google Scholar]
- SPAIN D. M., KAUFMAN G. The basic lesion in chronic pulmonary emphysema. Am Rev Tuberc. 1953 Jul;68(1):24–30. doi: 10.1164/art.1953.68.1.24. [DOI] [PubMed] [Google Scholar]
- Silvers G. W., Maisel J. C., Petty T. L., Mitchell R. S., Filley G. F. Central airway resistance in excised emphysematous lungs. Chest. 1972 Jun;61(7):603–612. doi: 10.1378/chest.61.7.603. [DOI] [PubMed] [Google Scholar]