Abstract
The lungs from an unselected group of necropsies were fixed in inflation by boiling formaldehyde vapour, and the percentage of emphysema was determined by macroscopic point-counting. The emphysema was categorized into alveolar, centrilobular, bullous, and `mixed'. The term `mixed' emphysema was applied to cases which had a combination of two or all of the three forms.
Quantitative criteria were used in the diagnosis of emphysema. `Significant' emphysema was defined as destruction of the lung parenchyma by 5% or more of centrilobular or 10% or more of alveolar or bullous emphysema.
Using these criteria, the overall incidence of emphysema in both sexes was 24%, the incidence in men being 35% and in women 9%. Alveolar emphysema was present in 25% of males and in 3% of females. The corresponding figures for centrilobular emphysema were 6% and 3%. Comparison of the present investigation with other studies suggests that there are geographical differences in the incidence of the alveolar and centrilobular forms of the disease.
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Selected References
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- Boushy S. F., Greenberg S. D., Jenkins D. E. The prevalence of emphysema in 67 unselected male necropsies. Dis Chest. 1968 Apr;53(4):497–501. doi: 10.1378/chest.53.4.497. [DOI] [PubMed] [Google Scholar]
- Edwards C., Heath D., Harris P. The carotid body in emphysema and left ventricular hypertrophy. J Pathol. 1971 May;104(1):1–13. doi: 10.1002/path.1711040102. [DOI] [PubMed] [Google Scholar]
- FLETCHER C. M. The clinical diagnosis of pulmonary emphysema; an experimental study. Proc R Soc Med. 1952 Sep;45(9):577–584. [PubMed] [Google Scholar]
- Hayes J. A., Summerell J. M. Emphysema in a non-industrialized tropical island. Thorax. 1969 Sep;24(5):623–625. doi: 10.1136/thx.24.5.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hicken P., Heath D., Brewer D. The relation between the weight of the right ventricle and the percentage of abnormal air space in the lung in emphysema. J Pathol Bacteriol. 1966 Oct;92(2):519–528. doi: 10.1002/path.1700920230. [DOI] [PubMed] [Google Scholar]
- LEOPOLD J. G., GOUGH J. The centrilobular form of hypertrophic emphysema and its relation to chronic bronchitis. Thorax. 1957 Sep;12(3):219–235. doi: 10.1136/thx.12.3.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts G. H., Scott K. W. A necropsy study of pulmonary emphysema in Glasgow. Thorax. 1972 Jan;27(1):28–32. doi: 10.1136/thx.27.1.28. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH K. V. A SURVEY OF THE TYPES AND SEVERITY OF EMPHYSEMA IN ROUTINE AUTOPSIES. Australas Ann Med. 1965 Feb;14:28–34. doi: 10.1111/imj.1965.14.1.28. [DOI] [PubMed] [Google Scholar]
- THURLBECK W. M. The incidence of pulmonary emphysema, with observations on the relative incidence and spatial distribution of various types of emphysema. Am Rev Respir Dis. 1963 Feb;87:206–215. doi: 10.1164/arrd.1963.87.2.206. [DOI] [PubMed] [Google Scholar]
- WALKER J. B. The detection of latent diabetes. Postgrad Med J. 1959 May;35(403):302–307. doi: 10.1136/pgmj.35.403.302. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEIBEL E. R., VIDONE R. A. Fixation of the lung by formalin steam in a controlled state of air inflation. Am Rev Respir Dis. 1961 Dec;84:856–861. doi: 10.1164/arrd.1961.84.6.856. [DOI] [PubMed] [Google Scholar]