Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1972 Sep;27(5):591–593. doi: 10.1136/thx.27.5.591

Haemodynamic effects of glucagon after mitral valve replacement

G H Smith 1, K Chandra 1
PMCID: PMC470559  PMID: 4563399

Abstract

We have studied six patients who had undergone mitral valve replacement. Estimations of cardiac output and of pulmonary vascular resistance were made, beginning two hours after the finish of the operation. Glucagon, 10 mg, was given intravenously, and cardiac output and pulmonary vascular resistance were measured 5 minutes and 30 minutes later. In all six cases there was a significant decrease in pulmonary vascular resistance and this occurred whether the resistance was slightly, moderately or greatly elevated. There was a highly significant increase in cardiac output in all cases.

Full text

PDF
591

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAUNWALD E., BRAUNWALD N. S., ROSS J., Jr, MORROW A. G. EFFECTS OF MITRAL-VALVE REPLACEMENT ON THE PULMONARY VASCULAR DYNAMICS OF PATIENTS WITH PULMONARY HYPERTENSION. N Engl J Med. 1965 Sep 2;273:509–514. doi: 10.1056/NEJM196509022731001. [DOI] [PubMed] [Google Scholar]
  2. FARAH A., TUTTLE R. Studies on the pharmacology of glucagon. J Pharmacol Exp Ther. 1960 May;129:49–55. [PubMed] [Google Scholar]
  3. Glick G., Parmley W. W., Wechsler A. S., Sonnenblick E. H. Glucagon. Its enhancement of cardiac performance in the cat and dog and persistence of its inotropic action despite beta-receptor blockade with propranolol. Circ Res. 1968 Jun;22(6):789–799. doi: 10.1161/01.res.22.6.789. [DOI] [PubMed] [Google Scholar]
  4. Klein S. W., Morch J. E., Mahon W. A. Cardiovascular effects of glucagon in man. Can Med Assoc J. 1968 Jun 22;98(25):1161–1164. [PMC free article] [PubMed] [Google Scholar]
  5. Lal S., Fletcher E. Glucagon therapy in heart-failure. Lancet. 1969 Apr 5;1(7597):731–731. doi: 10.1016/s0140-6736(69)92681-6. [DOI] [PubMed] [Google Scholar]
  6. Linhart J. W., Barold S. S., Cohen L. S., Hildner F. J., Samet P. Cardiovascular effects of glucagon in man. Am J Cardiol. 1968 Nov;22(5):706–710. doi: 10.1016/0002-9149(68)90209-9. [DOI] [PubMed] [Google Scholar]
  7. Lucchesi B. R. Cardiac actions of glucagon. Circ Res. 1968 Jun;22(6):777–787. doi: 10.1161/01.res.22.6.777. [DOI] [PubMed] [Google Scholar]
  8. Murtagh J. G., Binnion P. F., Lal S., Hutchison K. J., Fletcher E. Haemodynamic effects of glucagon. Br Heart J. 1970 May;32(3):307–315. doi: 10.1136/hrt.32.3.307. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. REGAN T. J., LEHAN P. H., HENNEMAN D. H., BEHAR A., HELLEMS H. K. MYOCARDIAL METABOLIC AND CONTRACTILE RESPONSE TO GLUCAGON AND EPINEPHRINE. J Lab Clin Med. 1964 Apr;63:638–647. [PubMed] [Google Scholar]
  10. Rouleau C. A., Frye R. L., Ellis F. H., Jr Hemynamic state after open mitral valve replaceent and reconstruction. J Thorac Cardiovasc Surg. 1969 Dec;58(6):870–878. [PubMed] [Google Scholar]
  11. Williams J. F., Jr, Childress R. H., Chip J. N., Border J. F. Hemodynamic effects of glucagon in patients with heart disease. Circulation. 1969 Jan;39(1):38–47. doi: 10.1161/01.cir.39.1.38. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES