Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1977 Jun;32(3):269–274. doi: 10.1136/thx.32.3.269

Studies in chronic allergic bronchopulmonary aspergillosis. 3. Immunological findings.

J L Malo, J Longbottom, J Mitchell, R Hawkins, J Pepys
PMCID: PMC470596  PMID: 329461

Abstract

Precipitin tests by two different methods, double-diffusion (DD) and counterimmunoelectrophoresis (CIE), and measurements of total and specific IgE against Aspergillus fumigatus were made in 50 patients with chronic allergic bronchopulmonary aspergillosis and in three control groups--atopics with a positive immediate prick test to A. fumigatus but no evidence of allergic aspergillosis, atopics with a negative prick test to A. fumigatus, and non-atopics. Precipitins were found in 84% and 78% of the patients with aspergillosis by the DD and CIE methods respectively. Precipitins were also found in 6 out of 27 (22%) patients with a positive prick test to A. fumigatus but no evidence of aspergillosis and in 1 of 24 patients with a negative prick test to A. fumigatus. The means of specific and total IgE values were significantly higher in the group of patients with aspergillosis than in the three other groups of patients. The increase in specific but not total IgE showed a statistically significant correlation with positive precipitin tests in the patients with aspergillosis. Total IgE but not specific IgE values were significantly higher (0-02 less than P less than 0-05) in patients who had had a transient radiographic shadow in the previous three months. Positive precipitin tests were also significantly correlated with the number of transient shadows in the past and with the interval of time since the last transient shadow.

Full text

PDF
269

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARBORIAK J. J., SOSMAN A. J., REED C. E. SEROLOGICAL STUDIES IN PIGEON BREEDER'S DISEASE. J Lab Clin Med. 1965 Apr;65:600–604. [PubMed] [Google Scholar]
  2. CAMPBELL M. J., CLAYTON Y. M. BRONCHOPULMONARY ASPERGILLOSIS. A CORRELATION OF THE CLINICAL AND LABORATORY FINDINGS IN 272 PATIENTS INVESTIGATED FOR BRONCHOPULMONARY ASPERGILLOSIS. Am Rev Respir Dis. 1964 Feb;89:186–196. doi: 10.1164/arrd.1964.89.2.186. [DOI] [PubMed] [Google Scholar]
  3. CULLIFORD B. J. PRECIPITIN REACTIONS IN FORENSIC PROBLEMS. A NEW METHOD FOR PRECIPITIN REACTIONS ON FORENSIC BLOOD, SEMEN AND SALIVA STAINS. Nature. 1964 Mar 14;201:1092–1093. doi: 10.1038/2011092a0. [DOI] [PubMed] [Google Scholar]
  4. Coleman R. M., Kaufman L. Use of the immunodiffusion test in the serodiagnosis of aspergillosis. Appl Microbiol. 1972 Feb;23(2):301–308. doi: 10.1128/am.23.2.301-308.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Flaherty D. K., Barboriak J., Emanuel D., Fink J., Marx J., Moore V., Reed C. E., Roberts R. Multilaboratory comparison of three immunodiffusion methods used for the detection of precipitating antibodies in hypersensitivity pneumonitis. J Lab Clin Med. 1974 Aug;84(2):298–306. [PubMed] [Google Scholar]
  6. LONGBOTTOM J. L., PEPYS J. PULMONARY ASPERGILLOSIS: DIAGNOSTIC AND IMMUNOLOGICAL SIGNIFICANCE OF ANTIGENS AND C-SUBSTANCE IN ASPERGILLUS FUMIGATUS. J Pathol Bacteriol. 1964 Jul;88:141–151. doi: 10.1002/path.1700880119. [DOI] [PubMed] [Google Scholar]
  7. Malo J. L., Hawkins R., Pepys J. Studies in chronic allergic bronchopulmonary aspergillosis. 1. Clinical and physiological findings. Thorax. 1977 Jun;32(3):254–261. doi: 10.1136/thx.32.3.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Malo J. L., Pepys J., Simon G. Studies in chronic allergic bronchopulmonary aspergillosis. 2. Radiological findings. Thorax. 1977 Jun;32(3):262–268. doi: 10.1136/thx.32.3.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. McCarthy D. S., Pepys J. Allergic broncho-pulmonary aspergillosis. Clinical immunology. 2. Skin, nasal and bronchial tests. Clin Allergy. 1971 Dec;1(4):415–432. doi: 10.1111/j.1365-2222.1971.tb00793.x. [DOI] [PubMed] [Google Scholar]
  10. Mearns M., Longbottom J., Batten J. Precipitating antibodies to aspergillus fumigatus in cystic fibrosis. Lancet. 1967 Mar 11;1(7489):538–539. doi: 10.1016/s0140-6736(67)92115-0. [DOI] [PubMed] [Google Scholar]
  11. PEPYS J., JENKINS P. A. PRECIPITIN (F.L.H.) TEST IN FARMER'S LUNG. Thorax. 1965 Jan;20:21–35. doi: 10.1136/thx.20.1.21. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Patterson R., Fink J. N., Pruzansky J. J., Reed C., Roberts M., Slavin R., Zeiss C. R. Serum immunoglobulin levels in pulmonary allergic aspergillosis and certain other lung diseases, with special reference to immunoglobulin E. Am J Med. 1973 Jan;54(1):16–22. doi: 10.1016/0002-9343(73)90078-8. [DOI] [PubMed] [Google Scholar]
  13. Patterson R., Roberts M. IgE and IgG antibodies against Aspergillus fumigatus in sera of patients with bronchopulmonary allergic aspergillosis. Int Arch Allergy Appl Immunol. 1974;46(1):150–160. doi: 10.1159/000231119. [DOI] [PubMed] [Google Scholar]
  14. Rowe D. S. Radioactive single radial diffusion: a method for increasing the sensitivity of immunochemical quantification of proteins in agar gel. Bull World Health Organ. 1969 Apr;40(4):613–616. [PMC free article] [PubMed] [Google Scholar]
  15. Safirstein B. H., D'Souza M. F., Simon G., Tai E. H., Pepys J. Five-year follow-up of allergic bronchopulmonary aspergillosis. Am Rev Respir Dis. 1973 Sep;108(3):450–459. doi: 10.1164/arrd.1973.108.3.450. [DOI] [PubMed] [Google Scholar]
  16. Turner K. J., Elder J. L., O'Mahony J., Johansson S. G. The association of lung shadowing with hypersensitivity responses in patients with allergic broncho-pulmonary aspergillosis. Clin Allergy. 1974 Jun;4(2):149–160. doi: 10.1111/j.1365-2222.1974.tb01372.x. [DOI] [PubMed] [Google Scholar]
  17. Ward G. W., Jr, Kohler P. F. Counterelectrophoresis as a rapid method for the detection of Aspergillus precipitins in pulmonary disease. Chest. 1973 Apr;63(Suppl):49S–51S. doi: 10.1378/chest.63.4_supplement.49s-a. [DOI] [PubMed] [Google Scholar]
  18. Wide L., Bennich H., Johansson S. G. Diagnosis of allergy by an in-vitro test for allergen antibodies. Lancet. 1967 Nov 25;2(7526):1105–1107. doi: 10.1016/s0140-6736(67)90615-0. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES